Linker histone H1.2 directs genome-wide chromatin association of the retinoblastoma tumor suppressor protein and facilitates its function

Linker histone H1.2 directs genome-wide chromatin association of the retinoblastoma tumor suppressor protein and facilitates its function

The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner. We establish that H1.2 and pRb are found in a ch...

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Detalles Bibliográficos
Autores principales: Munro, S, Hookway, E, Floderer, M, Carr, S, Konietzny, R, Kessler, B, Oppermann, U, La Thangue, N
Formato: Journal article
Lenguaje:English
Publicado: Elsevier 2017

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