Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota
We have shown previously that prebiotic (Bimuno galacto-oligosacharides, B-GOS®) administration to neonatal rats, increased hippocampal NMDAR proteins. The current study has investigated the effects of postnatal B-GOS® supplementation on hippocampusdependent behavior in young, adolescent and adult r...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2021
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| _version_ | 1826293916839706624 |
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| author | Spitzer, S Tkacz, A Savignac, H Cooper, M Giallourou, N Edward, M Bannerman, D Swann, J Anthony, D Poole, P Burnet, PW |
| author_facet | Spitzer, S Tkacz, A Savignac, H Cooper, M Giallourou, N Edward, M Bannerman, D Swann, J Anthony, D Poole, P Burnet, PW |
| author_sort | Spitzer, S |
| collection | OXFORD |
| description | We have shown previously that prebiotic (Bimuno galacto-oligosacharides, B-GOS®)
administration to neonatal rats, increased hippocampal NMDAR proteins. The current study
has investigated the effects of postnatal B-GOS® supplementation on hippocampusdependent behavior in young, adolescent and adult rats and applied electrophysiological,
metabolomic and metagenomic analyses to explore potential underlying mechanisms. The
administration of B-GOS® to suckling, but not post-weaned, rats reduced anxious behavior
until adulthood. Neonatal prebiotic intake also reduced the fast decay component of
hippocampal NMDA currents, altered age-specific trajectories of the brain, intestinal and liver
metabolomes, and reduced abundance of fecal Enterococcus and Dorea bacteria. Our data
are the first to show that prebiotic administration to rats during a specific postnatal period has
long-term effects on behavior and hippocampal physiology. The study also suggests that
early-life prebiotic intake may affect host brain function through the reduction of stress-related
gut bacteria rather than increasing the proliferation of beneficial microbes. |
| first_indexed | 2024-03-07T03:37:34Z |
| format | Journal article |
| id | oxford-uuid:bccd681b-6607-418c-8671-f020467a2448 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:37:34Z |
| publishDate | 2021 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:bccd681b-6607-418c-8671-f020467a24482022-03-27T05:27:11ZPostnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiotaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bccd681b-6607-418c-8671-f020467a2448EnglishSymplectic ElementsCell Press2021Spitzer, STkacz, ASavignac, HCooper, MGiallourou, NEdward, MBannerman, DSwann, JAnthony, DPoole, PBurnet, PWWe have shown previously that prebiotic (Bimuno galacto-oligosacharides, B-GOS®) administration to neonatal rats, increased hippocampal NMDAR proteins. The current study has investigated the effects of postnatal B-GOS® supplementation on hippocampusdependent behavior in young, adolescent and adult rats and applied electrophysiological, metabolomic and metagenomic analyses to explore potential underlying mechanisms. The administration of B-GOS® to suckling, but not post-weaned, rats reduced anxious behavior until adulthood. Neonatal prebiotic intake also reduced the fast decay component of hippocampal NMDA currents, altered age-specific trajectories of the brain, intestinal and liver metabolomes, and reduced abundance of fecal Enterococcus and Dorea bacteria. Our data are the first to show that prebiotic administration to rats during a specific postnatal period has long-term effects on behavior and hippocampal physiology. The study also suggests that early-life prebiotic intake may affect host brain function through the reduction of stress-related gut bacteria rather than increasing the proliferation of beneficial microbes. |
| spellingShingle | Spitzer, S Tkacz, A Savignac, H Cooper, M Giallourou, N Edward, M Bannerman, D Swann, J Anthony, D Poole, P Burnet, PW Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota |
| title | Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota |
| title_full | Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota |
| title_fullStr | Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota |
| title_full_unstemmed | Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota |
| title_short | Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota |
| title_sort | postnatal prebiotic supplementation in rats affects adult anxious behaviour hippocampus electrophysiology metabolomics and gut microbiota |
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