Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance.
During zidovudine therapy, human immunodeficiency virus type 1 (HIV-1) acquires a distinctive set of mutations that diminish the sensitivity of the virus to this drug in vitro. An AIDS patient is described who, while being treated with zidovudine, transmitted HIV-1 bearing a drug resistance mutation...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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| _version_ | 1797091805562404864 |
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| author | Conlon, C Klenerman, P Edwards, A Larder, B Phillips, R |
| author_facet | Conlon, C Klenerman, P Edwards, A Larder, B Phillips, R |
| author_sort | Conlon, C |
| collection | OXFORD |
| description | During zidovudine therapy, human immunodeficiency virus type 1 (HIV-1) acquires a distinctive set of mutations that diminish the sensitivity of the virus to this drug in vitro. An AIDS patient is described who, while being treated with zidovudine, transmitted HIV-1 bearing a drug resistance mutation to a young woman who had never received zidovudine treatment. DNA sequencing of HIV-1 proviruses confirmed that these 2 persons shared HIV genetic variants, including a mutation at codon 70 in the reverse transcriptase gene associated with reduced in vitro sensitivity to zidovudine. This mutation persisted in the woman > 1 year in the absence of antiretroviral therapy. HIV-1 with genetic markers of zidovudine resistance can be transmitted heterosexually, but it is uncertain whether dissemination of drug-resistant virus will substantially reduce the usefulness of this drug. |
| first_indexed | 2024-03-07T03:37:47Z |
| format | Journal article |
| id | oxford-uuid:bcda76d9-a593-4918-97b1-7e8ebd04ec01 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:37:47Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:bcda76d9-a593-4918-97b1-7e8ebd04ec012022-03-27T05:27:40ZHeterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bcda76d9-a593-4918-97b1-7e8ebd04ec01EnglishSymplectic Elements at Oxford1994Conlon, CKlenerman, PEdwards, ALarder, BPhillips, RDuring zidovudine therapy, human immunodeficiency virus type 1 (HIV-1) acquires a distinctive set of mutations that diminish the sensitivity of the virus to this drug in vitro. An AIDS patient is described who, while being treated with zidovudine, transmitted HIV-1 bearing a drug resistance mutation to a young woman who had never received zidovudine treatment. DNA sequencing of HIV-1 proviruses confirmed that these 2 persons shared HIV genetic variants, including a mutation at codon 70 in the reverse transcriptase gene associated with reduced in vitro sensitivity to zidovudine. This mutation persisted in the woman > 1 year in the absence of antiretroviral therapy. HIV-1 with genetic markers of zidovudine resistance can be transmitted heterosexually, but it is uncertain whether dissemination of drug-resistant virus will substantially reduce the usefulness of this drug. |
| spellingShingle | Conlon, C Klenerman, P Edwards, A Larder, B Phillips, R Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance. |
| title | Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance. |
| title_full | Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance. |
| title_fullStr | Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance. |
| title_full_unstemmed | Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance. |
| title_short | Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance. |
| title_sort | heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance |
| work_keys_str_mv | AT conlonc heterosexualtransmissionofhumanimmunodeficiencyvirustype1variantsassociatedwithzidovudineresistance AT klenermanp heterosexualtransmissionofhumanimmunodeficiencyvirustype1variantsassociatedwithzidovudineresistance AT edwardsa heterosexualtransmissionofhumanimmunodeficiencyvirustype1variantsassociatedwithzidovudineresistance AT larderb heterosexualtransmissionofhumanimmunodeficiencyvirustype1variantsassociatedwithzidovudineresistance AT phillipsr heterosexualtransmissionofhumanimmunodeficiencyvirustype1variantsassociatedwithzidovudineresistance |