Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria
The pharmacokinetic properties of piperaquine were investigated in 12 pregnant and 12 well-matched, non-pregnant women receiving a three-day oral fixed dose combination regimen of dihydroartemisinin and piperaquine for treatment of uncomplicated Plasmodium falciparum at New Halfa Hospital in eastern...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Society of Tropical Medicine and Hygiene
2012
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| _version_ | 1797091807865077760 |
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| author | Adam, I Tarning, J Lindegardh, N Mahgoub, H McGready, R Nosten, F |
| author_facet | Adam, I Tarning, J Lindegardh, N Mahgoub, H McGready, R Nosten, F |
| author_sort | Adam, I |
| collection | OXFORD |
| description | The pharmacokinetic properties of piperaquine were investigated in 12 pregnant and 12 well-matched, non-pregnant women receiving a three-day oral fixed dose combination regimen of dihydroartemisinin and piperaquine for treatment of uncomplicated Plasmodium falciparum at New Halfa Hospital in eastern Sudan. Frequent venous plasma samples were drawn from the patients over a 63-day period and a complete concentration-time profile was collected for 7 pregnant and 11 non-pregnant patients. Piperaquine was quantified using a liquid chromatography-mass spectrometry/mass spectrometry method. Pregnant women had a significantly higher total drug exposure (median area under the curve [range] = 1,770 [1,200-5,600] hr × ng/mL versus 858 [325-2,370] hr × ng/mL; P = 0.018) and longer time to maximal concentration (4.00 [1.50-4.03] hr versus 1.50 [0.500-8.00] hr; P = 0.02) after the first dose compared with non-pregnant women. There was no other significant difference observed in piperaquine pharmacokinetics between pregnant and non-pregnant women, including no difference in total drug exposure or maximum concentration. The overall pharmacokinetic properties of piperaquine in this study were consistent with previously published reports in non-pregnant patients. |
| first_indexed | 2024-03-07T03:37:49Z |
| format | Journal article |
| id | oxford-uuid:bcde23a6-4e50-406f-b44b-327118357f7e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:37:49Z |
| publishDate | 2012 |
| publisher | American Society of Tropical Medicine and Hygiene |
| record_format | dspace |
| spelling | oxford-uuid:bcde23a6-4e50-406f-b44b-327118357f7e2022-03-27T05:27:42ZPharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malariaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bcde23a6-4e50-406f-b44b-327118357f7eEnglishSymplectic Elements at OxfordAmerican Society of Tropical Medicine and Hygiene2012Adam, ITarning, JLindegardh, NMahgoub, HMcGready, RNosten, FThe pharmacokinetic properties of piperaquine were investigated in 12 pregnant and 12 well-matched, non-pregnant women receiving a three-day oral fixed dose combination regimen of dihydroartemisinin and piperaquine for treatment of uncomplicated Plasmodium falciparum at New Halfa Hospital in eastern Sudan. Frequent venous plasma samples were drawn from the patients over a 63-day period and a complete concentration-time profile was collected for 7 pregnant and 11 non-pregnant patients. Piperaquine was quantified using a liquid chromatography-mass spectrometry/mass spectrometry method. Pregnant women had a significantly higher total drug exposure (median area under the curve [range] = 1,770 [1,200-5,600] hr × ng/mL versus 858 [325-2,370] hr × ng/mL; P = 0.018) and longer time to maximal concentration (4.00 [1.50-4.03] hr versus 1.50 [0.500-8.00] hr; P = 0.02) after the first dose compared with non-pregnant women. There was no other significant difference observed in piperaquine pharmacokinetics between pregnant and non-pregnant women, including no difference in total drug exposure or maximum concentration. The overall pharmacokinetic properties of piperaquine in this study were consistent with previously published reports in non-pregnant patients. |
| spellingShingle | Adam, I Tarning, J Lindegardh, N Mahgoub, H McGready, R Nosten, F Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria |
| title | Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria |
| title_full | Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria |
| title_fullStr | Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria |
| title_full_unstemmed | Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria |
| title_short | Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria |
| title_sort | pharmacokinetics of piperaquine in pregnant women in sudan with uncomplicated plasmodium falciparum malaria |
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