5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.

BACKGROUND: The circulating form of folic acid, 5-methyltetrahydrofolate (5-MTHF), may have beneficial effects on endothelial function; however, its mechanisms of action remain uncertain. Decreased nitric oxide (NO) bioavailability and increased vascular superoxide production in vascular disease sta...

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Bibliographic Details
Main Authors: Antoniades, C, Shirodaria, C, Warrick, N, Cai, S, de Bono, J, Lee, J, Leeson, P, Neubauer, S, Ratnatunga, C, Pillai, R, Refsum, H, Channon, K
Format: Journal article
Language:English
Published: 2006

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