Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection
Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, d...
| 主要な著者: | , , , , , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
Lippincott, Williams & Wilkins
2019
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| _version_ | 1826313412810899456 |
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| author | Frater, J Martin, GE Willberg, CB Zilber, E Fox, J Nwokolo, N Fidler, S CHERUB Investigators |
| author_facet | Frater, J Martin, GE Willberg, CB Zilber, E Fox, J Nwokolo, N Fidler, S CHERUB Investigators |
| author_sort | Frater, J |
| collection | OXFORD |
| description | Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry. |
| first_indexed | 2024-03-07T03:38:04Z |
| format | Journal article |
| id | oxford-uuid:bcf5e6b5-a821-497b-ba70-db55cb7fe840 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:12:41Z |
| publishDate | 2019 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:bcf5e6b5-a821-497b-ba70-db55cb7fe8402024-07-01T10:48:47ZSoluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infectionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bcf5e6b5-a821-497b-ba70-db55cb7fe840EnglishSymplectic ElementsLippincott, Williams & Wilkins2019Frater, JMartin, GEWillberg, CBZilber, EFox, JNwokolo, NFidler, SCHERUB InvestigatorsSoluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry. |
| spellingShingle | Frater, J Martin, GE Willberg, CB Zilber, E Fox, J Nwokolo, N Fidler, S CHERUB Investigators Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection |
| title | Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection |
| title_full | Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection |
| title_fullStr | Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection |
| title_full_unstemmed | Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection |
| title_short | Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection |
| title_sort | soluble plasma programmed death 1 pd 1 and tim 3 in primary hiv infection |
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