Insights into Assessing the Genetics of Endometriosis.
Endometriosis is a complex disease arising from the interplay between multiple genetic and environmental factors. The genetic variants potentially underlying the hereditary component of endometriosis have been widely investigated through hypothesis-driven candidate gene studies, an approach that gen...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1826293959507312640 |
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| author | Rahmioglu, N Missmer, SA Montgomery, G Zondervan, K |
| author_facet | Rahmioglu, N Missmer, SA Montgomery, G Zondervan, K |
| author_sort | Rahmioglu, N |
| collection | OXFORD |
| description | Endometriosis is a complex disease arising from the interplay between multiple genetic and environmental factors. The genetic variants potentially underlying the hereditary component of endometriosis have been widely investigated through hypothesis-driven candidate gene studies, an approach that generally has proven to be inherently difficult and problematic for a number of reasons. Recently, through major collaborative efforts in the endometriosis research field, hypothesis-free genome-wide approaches have started to provide new insights into potential pathways leading to development of endometriosis, as well as highlighting the phenotypic heterogeneity of the condition. This review summarizes the most recent studies investigating the genetic variation contributing to endometriosis, with a particular focus on genome-wide approaches, and discusses promising future directions of genetic research. |
| first_indexed | 2024-03-07T03:38:14Z |
| format | Journal article |
| id | oxford-uuid:bd01dc70-47bf-4c9c-85f4-5e03ab307d0f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:38:14Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:bd01dc70-47bf-4c9c-85f4-5e03ab307d0f2022-03-27T05:28:37ZInsights into Assessing the Genetics of Endometriosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bd01dc70-47bf-4c9c-85f4-5e03ab307d0fEnglishSymplectic Elements at Oxford2012Rahmioglu, NMissmer, SAMontgomery, GZondervan, KEndometriosis is a complex disease arising from the interplay between multiple genetic and environmental factors. The genetic variants potentially underlying the hereditary component of endometriosis have been widely investigated through hypothesis-driven candidate gene studies, an approach that generally has proven to be inherently difficult and problematic for a number of reasons. Recently, through major collaborative efforts in the endometriosis research field, hypothesis-free genome-wide approaches have started to provide new insights into potential pathways leading to development of endometriosis, as well as highlighting the phenotypic heterogeneity of the condition. This review summarizes the most recent studies investigating the genetic variation contributing to endometriosis, with a particular focus on genome-wide approaches, and discusses promising future directions of genetic research. |
| spellingShingle | Rahmioglu, N Missmer, SA Montgomery, G Zondervan, K Insights into Assessing the Genetics of Endometriosis. |
| title | Insights into Assessing the Genetics of Endometriosis. |
| title_full | Insights into Assessing the Genetics of Endometriosis. |
| title_fullStr | Insights into Assessing the Genetics of Endometriosis. |
| title_full_unstemmed | Insights into Assessing the Genetics of Endometriosis. |
| title_short | Insights into Assessing the Genetics of Endometriosis. |
| title_sort | insights into assessing the genetics of endometriosis |
| work_keys_str_mv | AT rahmioglun insightsintoassessingthegeneticsofendometriosis AT missmersa insightsintoassessingthegeneticsofendometriosis AT montgomeryg insightsintoassessingthegeneticsofendometriosis AT zondervank insightsintoassessingthegeneticsofendometriosis |