Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin.

Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin.

MHC class I molecules expressed in a calreticulin-deficient cell line (K42) assembled with beta 2-microglobulin (beta2-m) normally, but their subsequent loading with optimal peptides was defective. Suboptimally loaded class I molecules were released into the secretory pathway. This occurred despite...

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Bibliographic Details
Main Authors:	Gao, B, Adhikari, R, Howarth, M, Nakamura, K, Gold, M, Hill, AB, Knee, R, Michalak, M, Elliott, T
Format:	Journal article
Language:	English
Published:	2002

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