Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

Effective agents to treat coronavirus infection are urgently required, not only to treat COVID-19, but to prepare for future outbreaks. Repurposed anti-virals such as remdesivir and human anti-inflammatories such as barcitinib have received emergency approval but their overall benefits remain unclea...

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Detalhes bibliográficos
Principais autores: Redhead, MA, Owen, CD, Brewitz, L, Collette, AH, Lukacik, P, Strain-Damerell, C, Robinson, SW, Collins, PM, Schäfer, P, Swindells, M, Radoux, CJ, Hopkins, IN, Fearon, D, Douangamath, A, von Delft, F, Malla, TR, Vangeel, L, Vercruysse, T, Thibaut, J, Leyssen, P, Nguyen, T-T, Hull, M, Tumber, A, Hallett, DJ, Schofield, CJ, Stuart, DI, Hopkins, AL, Walsh, MA
Formato: Journal article
Idioma:English
Publicado em: Springer Nature 2021
Assuntos:
SARS-CoV-2
X-ray crystallography
Enzyme mechanisms
High-throughput screening

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