Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos.
In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Nature Publishing Group
2017
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| _version_ | 1797091887887155200 |
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| author | Wilson, R Coverley, D |
| author_facet | Wilson, R Coverley, D |
| author_sort | Wilson, R |
| collection | OXFORD |
| description | In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use it to demonstrate that malignant transformation compromises the DNA-nuclear matrix interface. |
| first_indexed | 2024-03-07T03:38:47Z |
| format | Journal article |
| id | oxford-uuid:bd2f8bca-4e0e-41a7-8c41-e9a6877a05d1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:38:47Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:bd2f8bca-4e0e-41a7-8c41-e9a6877a05d12022-03-27T05:29:49ZTransformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bd2f8bca-4e0e-41a7-8c41-e9a6877a05d1EnglishSymplectic Elements at OxfordNature Publishing Group2017Wilson, RCoverley, DIn higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use it to demonstrate that malignant transformation compromises the DNA-nuclear matrix interface. |
| spellingShingle | Wilson, R Coverley, D Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos. |
| title | Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos. |
| title_full | Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos. |
| title_fullStr | Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos. |
| title_full_unstemmed | Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos. |
| title_short | Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos. |
| title_sort | transformation induced changes in the dna nuclear matrix interface revealed by high throughput analysis of dna halos |
| work_keys_str_mv | AT wilsonr transformationinducedchangesinthednanuclearmatrixinterfacerevealedbyhighthroughputanalysisofdnahalos AT coverleyd transformationinducedchangesinthednanuclearmatrixinterfacerevealedbyhighthroughputanalysisofdnahalos |