Perivascular adipose tissue as an endocrine organ: the role of statins
Adipose tissue (AT), aside from being an energy storage site, functions as a source of cytokines, adipokines and other vasoactive molecules. Dysfunctional AT contributes to the development of cardiovascular disease by shifting to a pro-oxidant, pro-inflammatory phenotype. Perivascular AT (PVAT) is o...
| Main Authors: | , , |
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| Format: | Journal article |
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Bentham Science Publishers
2017
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| _version_ | 1797091910299418624 |
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| author | Sanna, F Margaritis, M Antoniades, C |
| author_facet | Sanna, F Margaritis, M Antoniades, C |
| author_sort | Sanna, F |
| collection | OXFORD |
| description | Adipose tissue (AT), aside from being an energy storage site, functions as a source of cytokines, adipokines and other vasoactive molecules. Dysfunctional AT contributes to the development of cardiovascular disease by shifting to a pro-oxidant, pro-inflammatory phenotype. Perivascular AT (PVAT) is of particular importance to the development of vascular disease, due to its close proximity to the vascular wall. Molecules released from PVAT can exert both pro- and anti-contractile effects, the balance of which plays a role in controlling vascular tone. Recent evidence supports the existence of reciprocal, two-way interactions between PVAT and the vascular wall. Statins, with their pivotal role in cardiovascular disease prevention, have been shown to exert lipid-lowering independent, pleiotropic effects on the vascular wall, some of which may be mediated by modulatory effects on PVAT inflammation and secretome. These effects of statins provide a paradigm for the development of new therapeutic agents aimed at modulating PVAT function, as a novel treatment strategy against cardiovascular disease. |
| first_indexed | 2024-03-07T03:39:08Z |
| format | Journal article |
| id | oxford-uuid:bd49768b-74ba-4b8c-83c0-6c19bff6c58d |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:39:08Z |
| publishDate | 2017 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | oxford-uuid:bd49768b-74ba-4b8c-83c0-6c19bff6c58d2022-03-27T05:30:41ZPerivascular adipose tissue as an endocrine organ: the role of statinsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bd49768b-74ba-4b8c-83c0-6c19bff6c58dSymplectic Elements at OxfordBentham Science Publishers2017Sanna, FMargaritis, MAntoniades, CAdipose tissue (AT), aside from being an energy storage site, functions as a source of cytokines, adipokines and other vasoactive molecules. Dysfunctional AT contributes to the development of cardiovascular disease by shifting to a pro-oxidant, pro-inflammatory phenotype. Perivascular AT (PVAT) is of particular importance to the development of vascular disease, due to its close proximity to the vascular wall. Molecules released from PVAT can exert both pro- and anti-contractile effects, the balance of which plays a role in controlling vascular tone. Recent evidence supports the existence of reciprocal, two-way interactions between PVAT and the vascular wall. Statins, with their pivotal role in cardiovascular disease prevention, have been shown to exert lipid-lowering independent, pleiotropic effects on the vascular wall, some of which may be mediated by modulatory effects on PVAT inflammation and secretome. These effects of statins provide a paradigm for the development of new therapeutic agents aimed at modulating PVAT function, as a novel treatment strategy against cardiovascular disease. |
| spellingShingle | Sanna, F Margaritis, M Antoniades, C Perivascular adipose tissue as an endocrine organ: the role of statins |
| title | Perivascular adipose tissue as an endocrine organ: the role of statins |
| title_full | Perivascular adipose tissue as an endocrine organ: the role of statins |
| title_fullStr | Perivascular adipose tissue as an endocrine organ: the role of statins |
| title_full_unstemmed | Perivascular adipose tissue as an endocrine organ: the role of statins |
| title_short | Perivascular adipose tissue as an endocrine organ: the role of statins |
| title_sort | perivascular adipose tissue as an endocrine organ the role of statins |
| work_keys_str_mv | AT sannaf perivascularadiposetissueasanendocrineorgantheroleofstatins AT margaritism perivascularadiposetissueasanendocrineorgantheroleofstatins AT antoniadesc perivascularadiposetissueasanendocrineorgantheroleofstatins |