Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation.

A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium-catalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50 % is a large improvement over the single, previous synthesis. By design, this modular route allows the r...

詳細記述

書誌詳細
主要な著者: Gatland, A, Pilgrim, B, Procopiou, P, Donohoe, T
フォーマット: Journal article
言語:English
出版事項: Wiley 2014