Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation.

A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium-catalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50 % is a large improvement over the single, previous synthesis. By design, this modular route allows the r...

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Những tác giả chính: Gatland, A, Pilgrim, B, Procopiou, P, Donohoe, T
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Wiley 2014

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