Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation.
A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium-catalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50 % is a large improvement over the single, previous synthesis. By design, this modular route allows the r...
Những tác giả chính: | Gatland, A, Pilgrim, B, Procopiou, P, Donohoe, T |
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Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
Wiley
2014
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