Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation.

Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation.

A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium-catalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50 % is a large improvement over the single, previous synthesis. By design, this modular route allows the r...

Detaylı Bibliyografya
Asıl Yazarlar:	Gatland, A, Pilgrim, B, Procopiou, P, Donohoe, T
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Wiley 2014

Benzer Materyaller

Palladium-catalyzed enolate arylation as a key C-C bond-forming reaction for the synthesis of isoquinolines.
Yazar:: Pilgrim, B, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization.
Yazar:: Pilgrim, B, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Palladium-catalysed enolate arylation in the synthesis of isoquinolines
Yazar:: Gatland, A, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Expedient synthesis of substituted aromatics via the alpha-arylation of enolates
Yazar:: Pilgrim, B, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.
Yazar:: Donohoe, T, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Palladium-catalyzed intramolecular O-arylation of enolates: application to benzo[b]furan synthesis.
Yazar:: Willis, M, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Protoberberine Isoquinoline Alkaloids from Arcangelisia gusanlung
Yazar:: Ling-Ling Yu, ve diğerleri
Baskı/Yayın Bilgisi: (2014-08-01)

Palladium-catalyzed aryl halide carbonylation-intramolecular O-enolate acylation: efficient isocoumarin synthesis, including the synthesis of thunberginol A.
Yazar:: Tadd, A, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Palladium-catalysed intramolecular enolate O-arylation and thio-enolate S-arylation: synthesis of benzo[b]furans and benzo[b]thiophenes
Yazar:: Willis, M, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Palladium catalysed aryl enol ether synthesis from vinyl triflates.
Yazar:: Willis, M, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Palladium-catalysed enolate arylation in the synthesis of aromatic heterocycles and substituted heterocycles
Yazar:: Esteves, C
Baskı/Yayın Bilgisi: (2017)

Palladium-catalyzed aminosulfonylation of aryl halides.
Yazar:: Nguyen, B, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Palladium-Catalyzed Esterification of Aryl Fluorosulfates with Aryl Formates
Yazar:: Xue Chen, ve diğerleri
Baskı/Yayın Bilgisi: (2024-04-01)

Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles.
Yazar:: Potukuchi, H, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Efficient palladium-catalysed enamide synthesis from enol triflates and enol tosylates
Yazar:: Willis, M, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Entropy-Driven Inclusion of Natural Protoberberine Alkaloids in Sulfobutylether-β-Cyclodextrin
Yazar:: Zsombor Miskolczy, ve diğerleri
Baskı/Yayın Bilgisi: (2022-11-01)

Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids
Yazar:: Yifei Liu, ve diğerleri
Baskı/Yayın Bilgisi: (2021-06-01)

The Palladium-Catalyzed Trifluoromethylation of Aryl Chlorides
Yazar:: Cho, Eun Jin, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Palladium-catalyzed alpha-arylation of oxindoles.
Yazar:: Durbin, M, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Benzo[b]furan synthesis via palladium-catailysed intramolecular o-arylation of enolates.
Yazar:: Taylor, D, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Catalytic enolate arylation with 3-bromoindoles allows the formation of β-carbolines.
Yazar:: Alves Esteves, C, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Efficient Palladium-Catalyzed Synthesis of 2-Aryl Propionic Acids
Yazar:: Helfried Neumann, ve diğerleri
Baskı/Yayın Bilgisi: (2020-07-01)

Palladium-Catalyzed Synthesis of N-Aryl Carbamates
Yazar:: Fors, Brett P., ve diğerleri
Baskı/Yayın Bilgisi: (2015)

A concise enzyme cascade enables the manufacture of natural and halogenated protoberberine alkaloids
Yazar:: Fei Li, ve diğerleri
Baskı/Yayın Bilgisi: (2025-02-01)

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast
Yazar:: Xiang Jiao, ve diğerleri
Baskı/Yayın Bilgisi: (2024-10-01)

Neuroprotective role of a protoberberine alkaloid against aluminum-induced neuroinflammation and excitotoxicity
Yazar:: Ratna BABURAJ, ve diğerleri
Baskı/Yayın Bilgisi: (2023-06-01)

Palladium(0)-Catalyzed Arylative Dearomatization of Phenols
Yazar:: Rousseaux, Sophie, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Palladium-Catalyzed N-Arylation of 2-Aminothiazoles
Yazar:: McGowan, Meredeth A., ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Palladium(0)-catalyzed arylative dearomatization of phenols.
Yazar:: Rousseaux, S, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles
Yazar:: Jiao, Zhiwei, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Palladium-Catalyzed Regioselective Arylation of Unprotected Allylamines
Yazar:: Vinod G. Landge, ve diğerleri
Baskı/Yayın Bilgisi: (2020-12-01)

Reactivity of bromoselenophenes in palladium-catalyzed direct arylations
Yazar:: Aymen Skhiri, ve diğerleri
Baskı/Yayın Bilgisi: (2017-12-01)

Palladium-catalyzed cyclobutenation of aryl chlorides with norbornenes
Yazar:: Zhenkun Chen, ve diğerleri
Baskı/Yayın Bilgisi: (2022-02-01)

Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones
Yazar:: Jiao, Zhiwei, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Intramolecular palladium-catalyzed direct arylation of alkenyl triflates.
Yazar:: Cruz, A, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor
Yazar:: Adam Morel, ve diğerleri
Baskı/Yayın Bilgisi: (2014-06-01)

Intramolecular palladium-catalyzed alkane C-H arylation from aryl chlorides.
Yazar:: Rousseaux, S, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Pyruvate enolate arylation and alkylation: OBO ester protected pyruvates as useful reagents in organic synthesis
Yazar:: Alves Esteves, C, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Palladium-catalysed synthesis of isoquinolines
Yazar:: Pilgrim, B, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Palladium-Catalyzed Conversion of Aryl and Vinyl Triflates to Bromides and Chlorides
Yazar:: Shen, Xiaoqiang, ve diğerleri
Baskı/Yayın Bilgisi: (2012)