Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo.

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo.

(13)C MR spectroscopy studies performed on hearts ex vivo and in vivo following perfusion of prepolarized [1-(13)C]pyruvate have shown that changes in pyruvate dehydrogenase (PDH) flux may be monitored non-invasively. However, to allow investigation of Krebs cycle metabolism, the (13)C label must be...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Chen, A, Hurd, R, Schroeder, M, Lau, A, Gu, Y, Lam, W, Barry, J, Tropp, J, Cunningham, C
Format:	Journal article
Język:	English
Wydane:	2012

Podobne zapisy

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2- C ]pyruvate in vivo
od: Chen, A, i wsp.
Wydane: (2012)

Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes
od: Priestman, D, i wsp.
Wydane: (1997)

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
od: Schroeder, M, i wsp.
Wydane: (2008)

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
od: Timm, KN, i wsp.
Wydane: (2018)

Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.
od: Schroeder, M, i wsp.
Wydane: (2011)

REAL-TIME ASSESSMENT OF KREBS CYCLE METABOLISM WITH HYPERPOLARISED [2-13C]PYRUVATE
od: Atherton, H, i wsp.
Wydane: (2010)

Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart.
od: Lau, A, i wsp.
Wydane: (2010)

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
od: Koukourakis, M, i wsp.
Wydane: (2005)

CHRONIC HYPOXIA CAUSES NO CHANGE IN CARDIAC PYRUVATE DEHYDROGENASE FLUX IN THE CONTROL OR DIABETIC RAT: AN IN VIVO STUDY
od: Le Page, L, i wsp.
Wydane: (2013)

Fatty acids and the regulation of pyruvate dehydrogenase interconversion
od: Stewart, M, i wsp.
Wydane: (1997)

Design of spectral-spatial outer volume suppression RF pulses for tissue specific metabolic characterization with hyperpolarized 13C pyruvate.
od: Chen, A, i wsp.
Wydane: (2009)

Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy
od: Lewis, A, i wsp.
Wydane: (2016)

In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate.
od: Hu, S, i wsp.
Wydane: (2009)

Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate
od: Lau, A, i wsp.
Wydane: (2016)

Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.
od: Schroeder, M, i wsp.
Wydane: (2013)

Hyperpolarized magnetic resonance shows that the antiischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved postischemic function in the diabetic heart
od: Savic, D, i wsp.
Wydane: (2021)

Assessment of Metformin Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.
od: Lewis, A, i wsp.
Wydane: (2016)

Pyruvate dehydrogenase E2 deficiency: a potentially treatable cause of episodic dystonia.
od: McWilliam, C, i wsp.
Wydane: (2010)

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.
od: Atherton, H, i wsp.
Wydane: (2011)

Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.
od: Vijayakrishnan, S, i wsp.
Wydane: (2010)

Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly
od: Vijayakrishnan, S, i wsp.
Wydane: (2010)

Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.
od: Atherton, H, i wsp.
Wydane: (2011)

Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein–protein interactions by the MDM2 ligand nutlin-3
od: Way, L, i wsp.
Wydane: (2016)

Non-invasive assessment of metformin induced changes in cardiac and hepatic redox state using hyperpolarized [1–13C] pyruvate
od: Lewis, A, i wsp.
Wydane: (2016)

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain
od: Healicon, R, i wsp.
Wydane: (2022)

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
od: Forteza, MJ, i wsp.
Wydane: (2023)

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
od: Mohammad, G, i wsp.
Wydane: (2016)

Structural studies on pyruvate kinase
od: Fell, D
Wydane: (1974)

Pyruvate enolate arylation and alkylation: OBO ester protected pyruvates as useful reagents in organic synthesis
od: Alves Esteves, C, i wsp.
Wydane: (2017)

Somatic mosaicism for a PDHA1 mutation in a female with pyruvate dehydrogenase deficiency
od: Ridout, C, i wsp.
Wydane: (2008)

Somatic mosaicism for a PDHA1 mutation in a female with pyruvate dehydrogenase deficiency.
od: Ridout, C, i wsp.
Wydane: (2008)

Targeting pyruvate kinase M2 and lactate dehydrogenase A is an effective combination strategy for the treatment of pancreatic cancer
od: Mohammad, G, i wsp.
Wydane: (2019)

Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1‐13C]pyruvate and 13C‐urea
od: Lau, A, i wsp.
Wydane: (2016)

STRUCTURES OF PYRUVATE-KINASE AND PHOSPHOGLUCOSE ISOMERASE
od: Muirhead, H, i wsp.
Wydane: (1975)

Quantifying normal human brain metabolism using hyperpolarized [1–13C]pyruvate and magnetic resonance imaging
od: Grist, JT, i wsp.
Wydane: (2019)

Mutations in the gene for the E1β subunit: a novel cause of pyruvate dehydrogenase deficiency
od: Brown, R, i wsp.
Wydane: (2004)

Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase
od: Priestman, D, i wsp.
Wydane: (1994)

Investigation of pharmacological and physiological regulation of pyruvate dehydrogenase in diabetes using hyperpolarised magnetic resonance spectroscopy
od: Le Page, L
Wydane: (2014)

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
od: Schroeder, M, i wsp.
Wydane: (2009)

Pyruvate kinase: Function, regulation and role in cancer
od: Israelsen, William James, i wsp.
Wydane: (2016)