HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation

Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections. The natural HLA-E ligand is a signal peptide derived from classical class Ia HLA molecules that interact with the NKG2/CD...

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Detalhes bibliográficos
Principais autores:	Yang, H, Sun, H, Brackenridge, S, Zhuang, X, Wing, PAC, Quastel, M, Walters, L, Garner, L, Wang, B, Yao, X, Felce, SL, Peng, Y, Moore, S, Peeters, BWA, Rei, M, Canto Gomes, J, Tomas, A, Davidson, A, Semple, MG, Turtle, LCW, Openshaw, PJM, Baillie, JK, Mentzer, AJ, Klenerman, P, ISARIC4C Investigators, Borrow, P, Dong, T, McKeating, JA, Gillespie, GM, McMichael, AJ
Formato:	Journal article
Idioma:	English
Publicado em:	American Association for the Advancement of Science 2023

HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation

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