Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

Hypoxia-inducible factor (HIF)-1alpha, a master regulator of oxygen homeostasis, regulates genes crucial for cell growth and survival. In normoxia, HIF-1alpha is constantly degraded via the ubiquitin-proteasome pathway. The von Hippel-Lindau (VHL) E3 ubiquitin ligase binds HIF-1alpha through specifi...

Bibliográfalaš dieđut
Váldodahkkit:	Kageyama, Y, Koshiji, M, To, K, Tian, Y, Ratcliffe, P, Huang, L
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2004

Geahča maid

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