Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools.Here we first determined that the cis conformation of the succinate backbone is preferred and that certain...

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Bibliografiske detaljer
Main Authors:	Trauelsen, M, Ulven, E, Hjorth, SA, Brvar, M, Monaco, C, Frimurer, TM, Schwartz, TW
Format:	Journal article
Sprog:	English
Udgivet:	Elsevier 2017

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