Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.

Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.

Overproduction of nitric oxide (NO) by inducible NO synthase contributes toward refractory hypotension, impaired microvascular perfusion, and end-organ damage in septic shock patients. Tetrahydrobiopterin (BH4) is an essential NOS cofactor. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for...

Полное описание

Библиографические подробности
Главные авторы:	Starr, A, Sand, C, Heikal, L, Kelly, P, Spina, D, Crabtree, M, Channon, K, Leiper, J, Nandi, M
Формат:	Journal article
Язык:	English
Опубликовано:	2014

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