Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.

Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.

Overproduction of nitric oxide (NO) by inducible NO synthase contributes toward refractory hypotension, impaired microvascular perfusion, and end-organ damage in septic shock patients. Tetrahydrobiopterin (BH4) is an essential NOS cofactor. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for...

書目詳細資料
Main Authors:	Starr, A, Sand, C, Heikal, L, Kelly, P, Spina, D, Crabtree, M, Channon, K, Leiper, J, Nandi, M
格式:	Journal article
語言:	English
出版:	2014

相似書籍

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
由: Tatham, A, et al.
出版: (2009)

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
由: Hussein, D, et al.
出版: (2015)

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
由: Ryan, B, et al.
出版: (2014)

Endothelial-specific GTP cyclohydrolase overexpression reduces blood pressure in salt-sensitive hypertension
由: Chen, A, et al.
出版: (2006)

Cardiomyocyte-Targeted Overexpression of GTP Cyclohydrolase-1 Increases Myocyte Lusitropy and Reduces Superoxide Production
由: Carnicer, R, et al.
出版: (2010)

Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension
由: Du, Y, et al.
出版: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension\
由: Du, Y, et al.
出版: (2005)

Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.
由: Wang, W, et al.
出版: (2008)

Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.
由: Liao, S, et al.
出版: (2007)

Endothelial-specific GTP cyclohydrolase I overexpression prevents blood pressure progression in salt-sensitive hypertension
由: Chen, A, et al.
出版: (2005)

Cardiomyocyte-targeted overexpression of GTP cyclohydrolase-1 increases nNOS activity and hastens myocardial relaxation
由: Carnicer, R, et al.
出版: (2011)

Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes.
由: Tie, L, et al.
出版: (2009)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
由: Chuaiphichai, S, et al.
出版: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
由: Chuaiphichai, S, et al.
出版: (2014)

GTP cyclohydrolase II structure and mechanism.
由: Ren, J, et al.
出版: (2005)

Endothelium-targeted GTP cyclohydrolase I overexpression inhibits wire injury-induced restenosis in mouse carotid artery
由: Chen, A, et al.
出版: (2005)

Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
由: Du, Y, et al.
出版: (2008)

Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
由: Yanan Liu, et al.
出版: (2017-06-01)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
由: Bendall, J, et al.
出版: (2004)

Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.
由: Ionova, I, et al.
出版: (2010)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
由: Khoo, J, et al.
出版: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
由: Chuaiphichai, S, et al.
出版: (2014)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
由: Alp, N, et al.
出版: (2003)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
由: Carnicer, R, et al.
出版: (2012)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
由: Carnicer, R, et al.
出版: (2012)

GTP cyclohydrolase as a novel mechanism for tumour growth
由: Chen, L, et al.
出版: (2015)

The protein partners of GTP cyclohydrolase I in rat organs.
由: Jianhai Du, et al.
出版: (2012-01-01)

Assay for GTP Cyclohydrolase II Activity in Bacterial Extracts
由: Svetlana Yurgel, et al.
出版: (2014-08-01)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
由: Alp, N, et al.
出版: (2004)

Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
由: Chuaiphichai, S, et al.
出版: (2021)

Tetrahydrobiopterin- and glutathionylation-dependent regulation of eNOS coupling: Relationships revealed by eNOS glutathionylation mutants in cells with tet-regulated GTP cyclohydrolase I expression
由: Crabtree, M, et al.
出版: (2012)

Decreased Cardiac Allograft Rejection in Mice Over-Expressing Human GTP Cyclohydrolase I.
由: Irina, I, et al.
出版: (2009)

Control of GTP Cyclohydrolase I Activity during Aggregation of Dictyostelium discoideum
由: Ziegler Irmgard, et al.
出版: (1995-08-01)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
由: Vanessa A. N. Kraft, et al.
出版: (2019-12-01)

Functional Studies on the Promoter Region of the Human GTP Cyclohydrolase I Gene
由: Gütlich Markus, et al.
出版: (1995-08-01)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
由: Adlam, D, et al.
出版: (2012)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
由: Adlam, D, et al.
出版: (2012)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
由: Alp, N, et al.
出版: (2003)

Increased GTP-cyclohydrolase I expression but not vitamin C treatment restored accelerated atherosclerotic lesion formation in apolipoprotein E-deficient mice overexpressing endothelial nitric oxide synthase
由: Takaya, T, et al.
出版: (2004)

Systemic adenovirus-mediated gene transfer of human GTP cyclohydrolase-1 increases liver, plasma and aortic tetrahydrobiopterin levels in mice
由: Alp, N, et al.
出版: (2002)