Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.

Progressive multifocal leukoencephalopathy (PML), caused by replication of JC virus in oligodendrocytes of immunocompromised patients, is diagnosed by polymerase chain reaction-based demonstration of JC virus DNA. We investigated whether MRI might be used to assess disease activity. Diffusion-weight...

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Những tác giả chính: Mader, I, Herrlinger, U, Klose, U, Schmidt, F, Küker, W
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2003
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author Mader, I
Herrlinger, U
Klose, U
Schmidt, F
Küker, W
author_facet Mader, I
Herrlinger, U
Klose, U
Schmidt, F
Küker, W
author_sort Mader, I
collection OXFORD
description Progressive multifocal leukoencephalopathy (PML), caused by replication of JC virus in oligodendrocytes of immunocompromised patients, is diagnosed by polymerase chain reaction-based demonstration of JC virus DNA. We investigated whether MRI might be used to assess disease activity. Diffusion-weighted imaging (DWI) was obtained in two patients with PML, in whom it was the only MRI sequence on which we could identify areas of progressive disease. The extent of abnormal diffusion appeared to correlate with the speed of clinical progression. DWI would thus seem to be of value in patients with PML.
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spelling oxford-uuid:bddf70b4-017e-4214-a39e-f173afbce7b62022-03-27T05:35:01ZProgressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bddf70b4-017e-4214-a39e-f173afbce7b6EnglishSymplectic Elements at Oxford2003Mader, IHerrlinger, UKlose, USchmidt, FKüker, WProgressive multifocal leukoencephalopathy (PML), caused by replication of JC virus in oligodendrocytes of immunocompromised patients, is diagnosed by polymerase chain reaction-based demonstration of JC virus DNA. We investigated whether MRI might be used to assess disease activity. Diffusion-weighted imaging (DWI) was obtained in two patients with PML, in whom it was the only MRI sequence on which we could identify areas of progressive disease. The extent of abnormal diffusion appeared to correlate with the speed of clinical progression. DWI would thus seem to be of value in patients with PML.
spellingShingle Mader, I
Herrlinger, U
Klose, U
Schmidt, F
Küker, W
Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.
title Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.
title_full Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.
title_fullStr Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.
title_full_unstemmed Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.
title_short Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.
title_sort progressive multifocal leukoencephalopathy analysis of lesion development with diffusion weighted mri
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