Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.
Progressive multifocal leukoencephalopathy (PML), caused by replication of JC virus in oligodendrocytes of immunocompromised patients, is diagnosed by polymerase chain reaction-based demonstration of JC virus DNA. We investigated whether MRI might be used to assess disease activity. Diffusion-weight...
| প্রধান লেখক: | , , , , |
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| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
2003
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| _version_ | 1826294133432516608 |
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| author | Mader, I Herrlinger, U Klose, U Schmidt, F Küker, W |
| author_facet | Mader, I Herrlinger, U Klose, U Schmidt, F Küker, W |
| author_sort | Mader, I |
| collection | OXFORD |
| description | Progressive multifocal leukoencephalopathy (PML), caused by replication of JC virus in oligodendrocytes of immunocompromised patients, is diagnosed by polymerase chain reaction-based demonstration of JC virus DNA. We investigated whether MRI might be used to assess disease activity. Diffusion-weighted imaging (DWI) was obtained in two patients with PML, in whom it was the only MRI sequence on which we could identify areas of progressive disease. The extent of abnormal diffusion appeared to correlate with the speed of clinical progression. DWI would thus seem to be of value in patients with PML. |
| first_indexed | 2024-03-07T03:40:56Z |
| format | Journal article |
| id | oxford-uuid:bddf70b4-017e-4214-a39e-f173afbce7b6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:40:56Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:bddf70b4-017e-4214-a39e-f173afbce7b62022-03-27T05:35:01ZProgressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bddf70b4-017e-4214-a39e-f173afbce7b6EnglishSymplectic Elements at Oxford2003Mader, IHerrlinger, UKlose, USchmidt, FKüker, WProgressive multifocal leukoencephalopathy (PML), caused by replication of JC virus in oligodendrocytes of immunocompromised patients, is diagnosed by polymerase chain reaction-based demonstration of JC virus DNA. We investigated whether MRI might be used to assess disease activity. Diffusion-weighted imaging (DWI) was obtained in two patients with PML, in whom it was the only MRI sequence on which we could identify areas of progressive disease. The extent of abnormal diffusion appeared to correlate with the speed of clinical progression. DWI would thus seem to be of value in patients with PML. |
| spellingShingle | Mader, I Herrlinger, U Klose, U Schmidt, F Küker, W Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI. |
| title | Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI. |
| title_full | Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI. |
| title_fullStr | Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI. |
| title_full_unstemmed | Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI. |
| title_short | Progressive multifocal leukoencephalopathy: analysis of lesion development with diffusion-weighted MRI. |
| title_sort | progressive multifocal leukoencephalopathy analysis of lesion development with diffusion weighted mri |
| work_keys_str_mv | AT maderi progressivemultifocalleukoencephalopathyanalysisoflesiondevelopmentwithdiffusionweightedmri AT herrlingeru progressivemultifocalleukoencephalopathyanalysisoflesiondevelopmentwithdiffusionweightedmri AT kloseu progressivemultifocalleukoencephalopathyanalysisoflesiondevelopmentwithdiffusionweightedmri AT schmidtf progressivemultifocalleukoencephalopathyanalysisoflesiondevelopmentwithdiffusionweightedmri AT kukerw progressivemultifocalleukoencephalopathyanalysisoflesiondevelopmentwithdiffusionweightedmri |