NMDA receptor antagonists can enhance or impair learning performance in animals.
The effects of NMDA receptor antagonism on learning and memory were investigated using competitive (DL-2-amino-7-phosphonoheptanoate, AP7) and non-competitive (MK 801) blockers in three different learning tasks. Administration (i.p.) of drugs prior to training resulted in impaired learning performan...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| _version_ | 1797092080621715456 |
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| author | Mondadori, C Weiskrantz, L Buerki, H Petschke, F Fagg, G |
| author_facet | Mondadori, C Weiskrantz, L Buerki, H Petschke, F Fagg, G |
| author_sort | Mondadori, C |
| collection | OXFORD |
| description | The effects of NMDA receptor antagonism on learning and memory were investigated using competitive (DL-2-amino-7-phosphonoheptanoate, AP7) and non-competitive (MK 801) blockers in three different learning tasks. Administration (i.p.) of drugs prior to training resulted in impaired learning performance in the place-navigation and dark-avoidance paradigms, and improved performance in the step-down passive avoidance task; however, using this treatment protocol, the possibility of drug-induced non-mnemonic effects modifying learning performance could not be excluded. Drug administration immediately post-trial had no effect in the place-navigation paradigm, and improved retention performance in the dark-avoidance and step-down avoidance tasks. The similar results obtained with both types of antagonist indicate that the observed effects are indeed due to NMDA receptor blockade, and hence that such blockade modifies learning in a task-dependent manner. Exclusion of non-mnemonic effects by using the post-trial treatment regime demonstrates that NMDA antagonists facilitate learning of passive avoidance tasks. |
| first_indexed | 2024-03-07T03:41:15Z |
| format | Journal article |
| id | oxford-uuid:bdf5f2a0-3a4a-4a47-ab0b-c3f7aba61790 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:41:15Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:bdf5f2a0-3a4a-4a47-ab0b-c3f7aba617902022-03-27T05:35:46ZNMDA receptor antagonists can enhance or impair learning performance in animals.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bdf5f2a0-3a4a-4a47-ab0b-c3f7aba61790EnglishSymplectic Elements at Oxford1989Mondadori, CWeiskrantz, LBuerki, HPetschke, FFagg, GThe effects of NMDA receptor antagonism on learning and memory were investigated using competitive (DL-2-amino-7-phosphonoheptanoate, AP7) and non-competitive (MK 801) blockers in three different learning tasks. Administration (i.p.) of drugs prior to training resulted in impaired learning performance in the place-navigation and dark-avoidance paradigms, and improved performance in the step-down passive avoidance task; however, using this treatment protocol, the possibility of drug-induced non-mnemonic effects modifying learning performance could not be excluded. Drug administration immediately post-trial had no effect in the place-navigation paradigm, and improved retention performance in the dark-avoidance and step-down avoidance tasks. The similar results obtained with both types of antagonist indicate that the observed effects are indeed due to NMDA receptor blockade, and hence that such blockade modifies learning in a task-dependent manner. Exclusion of non-mnemonic effects by using the post-trial treatment regime demonstrates that NMDA antagonists facilitate learning of passive avoidance tasks. |
| spellingShingle | Mondadori, C Weiskrantz, L Buerki, H Petschke, F Fagg, G NMDA receptor antagonists can enhance or impair learning performance in animals. |
| title | NMDA receptor antagonists can enhance or impair learning performance in animals. |
| title_full | NMDA receptor antagonists can enhance or impair learning performance in animals. |
| title_fullStr | NMDA receptor antagonists can enhance or impair learning performance in animals. |
| title_full_unstemmed | NMDA receptor antagonists can enhance or impair learning performance in animals. |
| title_short | NMDA receptor antagonists can enhance or impair learning performance in animals. |
| title_sort | nmda receptor antagonists can enhance or impair learning performance in animals |
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