Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design.
Understanding the antibody response in HIV-1 infection is important to vaccine design. We have studied the antibody response to HIV-1 envelope at the molecular level and determined the characteristics of neutralizing and non-neutralizing antibodies. These antibodies were isolated from phage display...
| Main Authors: | , , , , , , |
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| Format: | Conference item |
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1997
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| _version_ | 1826294164201930752 |
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| author | Parren, P Gauduin, M Koup, R Poignard, P Fisicaro, P Burton, DR Sattentau, Q |
| author_facet | Parren, P Gauduin, M Koup, R Poignard, P Fisicaro, P Burton, DR Sattentau, Q |
| author_sort | Parren, P |
| collection | OXFORD |
| description | Understanding the antibody response in HIV-1 infection is important to vaccine design. We have studied the antibody response to HIV-1 envelope at the molecular level and determined the characteristics of neutralizing and non-neutralizing antibodies. These antibodies were isolated from phage display libraries prepared from long-term seropositive asymptomatic individuals. The HIV-1 envelope is presented to the immune system in several antigenically distinct configurations: unprocessed gp160, gp120 and gp41 subunits and native envelope, each of which may be important in eliciting an antibody response in HIV-1 infection. The antibodies tested characteristically had poor affinities for native envelope as expressed on the surface of virions or infected cells, but had high affinities against non-native forms of HIV-1 envelope (viral debris). An exceptionally potent neutralizing antibody in contrast, bound native envelope with equivalent or somewhat higher affinity than this. This indicates that the antibody response in HIV-1 infection is principally elicited by viral debris rather than virions, and that these antibodies bind and neutralize viruses sub-optimally. Potential vaccines should be designed to elicit responses against native envelope. |
| first_indexed | 2024-03-07T03:41:25Z |
| format | Conference item |
| id | oxford-uuid:be05b919-48fc-4225-904e-a22d832fc0ac |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:41:25Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:be05b919-48fc-4225-904e-a22d832fc0ac2022-03-27T05:36:12ZRelevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:be05b919-48fc-4225-904e-a22d832fc0acSymplectic Elements at Oxford1997Parren, PGauduin, MKoup, RPoignard, PFisicaro, PBurton, DRSattentau, QUnderstanding the antibody response in HIV-1 infection is important to vaccine design. We have studied the antibody response to HIV-1 envelope at the molecular level and determined the characteristics of neutralizing and non-neutralizing antibodies. These antibodies were isolated from phage display libraries prepared from long-term seropositive asymptomatic individuals. The HIV-1 envelope is presented to the immune system in several antigenically distinct configurations: unprocessed gp160, gp120 and gp41 subunits and native envelope, each of which may be important in eliciting an antibody response in HIV-1 infection. The antibodies tested characteristically had poor affinities for native envelope as expressed on the surface of virions or infected cells, but had high affinities against non-native forms of HIV-1 envelope (viral debris). An exceptionally potent neutralizing antibody in contrast, bound native envelope with equivalent or somewhat higher affinity than this. This indicates that the antibody response in HIV-1 infection is principally elicited by viral debris rather than virions, and that these antibodies bind and neutralize viruses sub-optimally. Potential vaccines should be designed to elicit responses against native envelope. |
| spellingShingle | Parren, P Gauduin, M Koup, R Poignard, P Fisicaro, P Burton, DR Sattentau, Q Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. |
| title | Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. |
| title_full | Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. |
| title_fullStr | Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. |
| title_full_unstemmed | Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. |
| title_short | Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. |
| title_sort | relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design |
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