Turing's model for biological pattern formation and the robustness problem
One of the fundamental questions in developmental biology is how the vast range of pattern and structure we observe in nature emerges from an almost uniformly homogeneous fertilized egg. In particular, the mechanisms by which biological systems maintain robustness, despite being subject to numerous...
| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Journal article |
| Baskı/Yayın Bilgisi: |
Royal Society Publishing
2012
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| _version_ | 1826294173677912064 |
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| author | Maini, P Woolley, T Baker, R Gaffney, E Seirin Lee, S |
| author_facet | Maini, P Woolley, T Baker, R Gaffney, E Seirin Lee, S |
| author_sort | Maini, P |
| collection | OXFORD |
| description | One of the fundamental questions in developmental biology is how the vast range of pattern and structure we observe in nature emerges from an almost uniformly homogeneous fertilized egg. In particular, the mechanisms by which biological systems maintain robustness, despite being subject to numerous sources of noise, are shrouded in mystery. Postulating plausible theoretical models of biological heterogeneity is not only difficult, but it is also further complicated by the problem of generating robustness, i.e. once we can generate a pattern, how do we ensure that this pattern is consistently reproducible in the face of perturbations to the domain, reaction time scale, boundary conditions and so forth. In this paper, not only do we review the basic properties of Turing's theory, we highlight the successes and pitfalls of using it as a model for biological systems, and discuss emerging developments in the area. |
| first_indexed | 2024-03-07T03:41:33Z |
| format | Journal article |
| id | oxford-uuid:be0f75b7-d36a-40ea-aad9-29f4b7fe1f5a |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:41:33Z |
| publishDate | 2012 |
| publisher | Royal Society Publishing |
| record_format | dspace |
| spelling | oxford-uuid:be0f75b7-d36a-40ea-aad9-29f4b7fe1f5a2022-03-27T05:36:31ZTuring's model for biological pattern formation and the robustness problemJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:be0f75b7-d36a-40ea-aad9-29f4b7fe1f5aMathematical Institute - ePrintsRoyal Society Publishing2012Maini, PWoolley, TBaker, RGaffney, ESeirin Lee, SOne of the fundamental questions in developmental biology is how the vast range of pattern and structure we observe in nature emerges from an almost uniformly homogeneous fertilized egg. In particular, the mechanisms by which biological systems maintain robustness, despite being subject to numerous sources of noise, are shrouded in mystery. Postulating plausible theoretical models of biological heterogeneity is not only difficult, but it is also further complicated by the problem of generating robustness, i.e. once we can generate a pattern, how do we ensure that this pattern is consistently reproducible in the face of perturbations to the domain, reaction time scale, boundary conditions and so forth. In this paper, not only do we review the basic properties of Turing's theory, we highlight the successes and pitfalls of using it as a model for biological systems, and discuss emerging developments in the area. |
| spellingShingle | Maini, P Woolley, T Baker, R Gaffney, E Seirin Lee, S Turing's model for biological pattern formation and the robustness problem |
| title | Turing's model for biological pattern formation and the robustness problem |
| title_full | Turing's model for biological pattern formation and the robustness problem |
| title_fullStr | Turing's model for biological pattern formation and the robustness problem |
| title_full_unstemmed | Turing's model for biological pattern formation and the robustness problem |
| title_short | Turing's model for biological pattern formation and the robustness problem |
| title_sort | turing s model for biological pattern formation and the robustness problem |
| work_keys_str_mv | AT mainip turingsmodelforbiologicalpatternformationandtherobustnessproblem AT woolleyt turingsmodelforbiologicalpatternformationandtherobustnessproblem AT bakerr turingsmodelforbiologicalpatternformationandtherobustnessproblem AT gaffneye turingsmodelforbiologicalpatternformationandtherobustnessproblem AT seirinlees turingsmodelforbiologicalpatternformationandtherobustnessproblem |