The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.

MMP activities are controlled by a combination of proteolytic pro-enzyme activation steps and inhibition by endogenous inhibitors like alpha2-macroglobulin and the tissue inhibitors of metalloproteinases (TIMPs). TIMPs are the key inhibitors in tissue. The expression of both MMPs and TIMPs is contro...

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Hlavní autoři: Zhang, J, Bai, S, Tanase, C, Nagase, H, Sarras, M
Médium: Journal article
Jazyk:English
Vydáno: 2003