A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression.
Gray matter abnormalities within frontal-subcortical and limbic networks are hypothesized to play a key role in the pathophysiology of late-life depression. In this work, gray matter abnormalities in late-life depression are examined in a systematic review and meta-analysis of magnetic resonance ima...
| Egile Nagusiak: | , , |
|---|---|
| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2013
|
| _version_ | 1826294193988829184 |
|---|---|
| author | Sexton, C Mackay, C Ebmeier, K |
| author_facet | Sexton, C Mackay, C Ebmeier, K |
| author_sort | Sexton, C |
| collection | OXFORD |
| description | Gray matter abnormalities within frontal-subcortical and limbic networks are hypothesized to play a key role in the pathophysiology of late-life depression. In this work, gray matter abnormalities in late-life depression are examined in a systematic review and meta-analysis of magnetic resonance imaging studies. In the systematic review, 27 articles were identified that compared participants with late-life depression with comparison group participants, and 17 studies were suitable for inclusion in meta-analyses of volumes of the whole brain, orbitofrontal cortex, caudate, hippocampus, putamen, and thalamus. Volume reductions were detected in 7 of 15 comparisons of the hippocampus and a meta-analysis revealed a significant, but small, effect size. Although examined by fewer studies, meta-analyses also revealed significant volume reductions in the orbitofrontal cortex, putamen, and thalamus. A more systematic and comprehensive analysis of the global distribution of gray matter abnormalities, and an examination of subcortical abnormalities were identified as key areas for future research. |
| first_indexed | 2024-03-07T03:41:52Z |
| format | Journal article |
| id | oxford-uuid:be2c3acf-3bd9-4927-bf09-63eacf2c994b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:41:52Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:be2c3acf-3bd9-4927-bf09-63eacf2c994b2022-03-27T05:37:16ZA systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:be2c3acf-3bd9-4927-bf09-63eacf2c994bEnglishSymplectic Elements at Oxford2013Sexton, CMackay, CEbmeier, KGray matter abnormalities within frontal-subcortical and limbic networks are hypothesized to play a key role in the pathophysiology of late-life depression. In this work, gray matter abnormalities in late-life depression are examined in a systematic review and meta-analysis of magnetic resonance imaging studies. In the systematic review, 27 articles were identified that compared participants with late-life depression with comparison group participants, and 17 studies were suitable for inclusion in meta-analyses of volumes of the whole brain, orbitofrontal cortex, caudate, hippocampus, putamen, and thalamus. Volume reductions were detected in 7 of 15 comparisons of the hippocampus and a meta-analysis revealed a significant, but small, effect size. Although examined by fewer studies, meta-analyses also revealed significant volume reductions in the orbitofrontal cortex, putamen, and thalamus. A more systematic and comprehensive analysis of the global distribution of gray matter abnormalities, and an examination of subcortical abnormalities were identified as key areas for future research. |
| spellingShingle | Sexton, C Mackay, C Ebmeier, K A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. |
| title | A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. |
| title_full | A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. |
| title_fullStr | A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. |
| title_full_unstemmed | A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. |
| title_short | A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. |
| title_sort | systematic review and meta analysis of magnetic resonance imaging studies in late life depression |
| work_keys_str_mv | AT sextonc asystematicreviewandmetaanalysisofmagneticresonanceimagingstudiesinlatelifedepression AT mackayc asystematicreviewandmetaanalysisofmagneticresonanceimagingstudiesinlatelifedepression AT ebmeierk asystematicreviewandmetaanalysisofmagneticresonanceimagingstudiesinlatelifedepression AT sextonc systematicreviewandmetaanalysisofmagneticresonanceimagingstudiesinlatelifedepression AT mackayc systematicreviewandmetaanalysisofmagneticresonanceimagingstudiesinlatelifedepression AT ebmeierk systematicreviewandmetaanalysisofmagneticresonanceimagingstudiesinlatelifedepression |