Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease
Olfactory deficits are a common (often prodromal) symptom of neurodegenerative or psychiatric disorders. As such, olfaction could have great potential as an early biomarker of disease, for example using neuroimaging to investigate the breakdown of structural connectivity profile of the primary olfac...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Publishing Group
2017
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| _version_ | 1826294219065524224 |
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| author | Fjaeldstad, A Fernandes, H Van Hartevelt, T Gleesborg, C Møller, A Ovesen, T Kringelbach, M |
| author_facet | Fjaeldstad, A Fernandes, H Van Hartevelt, T Gleesborg, C Møller, A Ovesen, T Kringelbach, M |
| author_sort | Fjaeldstad, A |
| collection | OXFORD |
| description | Olfactory deficits are a common (often prodromal) symptom of neurodegenerative or psychiatric disorders. As such, olfaction could have great potential as an early biomarker of disease, for example using neuroimaging to investigate the breakdown of structural connectivity profile of the primary olfactory networks. We investigated the suitability for this purpose in two existing neuroimaging maps of olfactory networks. We found problems with both existing neuroimaging maps in terms of their structural connectivity to known secondary olfactory networks. Based on these findings, we were able to merge the existing maps to a new template map of olfactory networks with connections to all key secondary olfactory networks. We introduce a new method that combines diffusion tensor imaging with probabilistic tractography and pattern recognition techniques. This method can obtain comprehensive and reliable fingerprints of the structural connectivity underlying the neural processing of olfactory stimuli in normosmic adults. Combining the novel proposed method for structural fingerprinting with the template map of olfactory networks has great potential to be used for future neuroimaging investigations of olfactory function in disease. With time, the proposed method may even come to serve as structural biomarker for early detection of disease. |
| first_indexed | 2024-03-07T03:42:15Z |
| format | Journal article |
| id | oxford-uuid:be4c9a90-aae3-47d3-9699-5c44d81def60 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:42:15Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:be4c9a90-aae3-47d3-9699-5c44d81def602022-03-27T05:38:19ZBrain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:be4c9a90-aae3-47d3-9699-5c44d81def60Symplectic Elements at OxfordNature Publishing Group2017Fjaeldstad, AFernandes, HVan Hartevelt, TGleesborg, CMøller, AOvesen, TKringelbach, MOlfactory deficits are a common (often prodromal) symptom of neurodegenerative or psychiatric disorders. As such, olfaction could have great potential as an early biomarker of disease, for example using neuroimaging to investigate the breakdown of structural connectivity profile of the primary olfactory networks. We investigated the suitability for this purpose in two existing neuroimaging maps of olfactory networks. We found problems with both existing neuroimaging maps in terms of their structural connectivity to known secondary olfactory networks. Based on these findings, we were able to merge the existing maps to a new template map of olfactory networks with connections to all key secondary olfactory networks. We introduce a new method that combines diffusion tensor imaging with probabilistic tractography and pattern recognition techniques. This method can obtain comprehensive and reliable fingerprints of the structural connectivity underlying the neural processing of olfactory stimuli in normosmic adults. Combining the novel proposed method for structural fingerprinting with the template map of olfactory networks has great potential to be used for future neuroimaging investigations of olfactory function in disease. With time, the proposed method may even come to serve as structural biomarker for early detection of disease. |
| spellingShingle | Fjaeldstad, A Fernandes, H Van Hartevelt, T Gleesborg, C Møller, A Ovesen, T Kringelbach, M Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease |
| title | Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease |
| title_full | Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease |
| title_fullStr | Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease |
| title_full_unstemmed | Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease |
| title_short | Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease |
| title_sort | brain fingerprints of olfaction a novel structural method for assessing olfactory cortical networks in health and disease |
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