In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.

OBJECTIVE: To detect and determine disease severity of osteoarthritis (OA) using a probe activated by matrix metalloproteinase-13 (MMP-13) in vivo in the murine destabilised medial meniscus (DMM) surgical model of OA. DESIGN: We have previously described MMP12ap and MMP13ap, internally quenched fluo...

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Autori principali: Lim, N, Meinjohanns, E, Meldal, M, Bou-Gharios, G, Nagase, H
Natura: Journal article
Lingua:English
Pubblicazione: Elsevier 2014