Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children
<strong>Aim</strong> To examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood. <strong>Methods</strong> We conducted a cross-sectional, school-ba...
| Автори: | , , , , , , , , , , |
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| Формат: | Journal article |
| Опубліковано: |
Wiley
2015
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| _version_ | 1826294236155215872 |
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| author | Donin, A Dent, J Nightingale, C Sattar, N Owen, C Rudnicka, A Perkin, M Stephen, A Jebb, S Cook, D Whincup, P |
| author_facet | Donin, A Dent, J Nightingale, C Sattar, N Owen, C Rudnicka, A Perkin, M Stephen, A Jebb, S Cook, D Whincup, P |
| author_sort | Donin, A |
| collection | OXFORD |
| description | <strong>Aim</strong> To examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood. <strong>Methods</strong> We conducted a cross-sectional, school-based study in 2025 UK children aged 9–10 years, predominantly of white European, South-Asian and black African origin. A 24-h dietary recall was used to assess fruit, vegetable and vitamin C intakes. Height, weight and fat mass were measured and a fasting blood sample collected to measure plasma vitamin C concentrations and Type 2 diabetes risk markers. <strong>Results</strong> In analyses adjusting for confounding variables (including socio-economic status), a one interquartile range higher plasma vitamin C concentration (30.9 µmol/l) was associated with a 9.6% (95% CI 6.5, 12.6%) lower homeostatic model assessment of insulin resistance value, 0.8% (95% CI 0.4, 1.2%) lower fasting glucose, 4.5% (95% CI 3.2, 5.9%) lower urate and 2.2% (95% CI 0.9, 3.4%) higher HDL cholesterol. HbA1c concentration was 0.6% (95% CI 0.2, 1.0%) higher. Dietary fruit, vegetable and total vitamin C intakes were not associated with any Type 2 diabetes risk markers. Lower plasma vitamin C concentrations in SouthAsian and black African-Caribbean children could partly explain their higher insulin resistance. <strong>Conclusions</strong> Lower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Experimental studies are needed to establish whether increasing plasma vitamin C can help prevent Type 2 diabetes at an early stage. |
| first_indexed | 2024-03-07T03:42:31Z |
| format | Journal article |
| id | oxford-uuid:be63f051-1632-4edc-9614-a99e16427b1c |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:42:31Z |
| publishDate | 2015 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:be63f051-1632-4edc-9614-a99e16427b1c2022-03-27T05:39:10ZFruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old childrenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:be63f051-1632-4edc-9614-a99e16427b1cSymplectic Elements at OxfordWiley2015Donin, ADent, JNightingale, CSattar, NOwen, CRudnicka, APerkin, MStephen, AJebb, SCook, DWhincup, P<strong>Aim</strong> To examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood. <strong>Methods</strong> We conducted a cross-sectional, school-based study in 2025 UK children aged 9–10 years, predominantly of white European, South-Asian and black African origin. A 24-h dietary recall was used to assess fruit, vegetable and vitamin C intakes. Height, weight and fat mass were measured and a fasting blood sample collected to measure plasma vitamin C concentrations and Type 2 diabetes risk markers. <strong>Results</strong> In analyses adjusting for confounding variables (including socio-economic status), a one interquartile range higher plasma vitamin C concentration (30.9 µmol/l) was associated with a 9.6% (95% CI 6.5, 12.6%) lower homeostatic model assessment of insulin resistance value, 0.8% (95% CI 0.4, 1.2%) lower fasting glucose, 4.5% (95% CI 3.2, 5.9%) lower urate and 2.2% (95% CI 0.9, 3.4%) higher HDL cholesterol. HbA1c concentration was 0.6% (95% CI 0.2, 1.0%) higher. Dietary fruit, vegetable and total vitamin C intakes were not associated with any Type 2 diabetes risk markers. Lower plasma vitamin C concentrations in SouthAsian and black African-Caribbean children could partly explain their higher insulin resistance. <strong>Conclusions</strong> Lower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Experimental studies are needed to establish whether increasing plasma vitamin C can help prevent Type 2 diabetes at an early stage. |
| spellingShingle | Donin, A Dent, J Nightingale, C Sattar, N Owen, C Rudnicka, A Perkin, M Stephen, A Jebb, S Cook, D Whincup, P Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children |
| title | Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children |
| title_full | Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children |
| title_fullStr | Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children |
| title_full_unstemmed | Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children |
| title_short | Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children |
| title_sort | fruit vegetable and vitamin c intakes and plasma vitamin c cross sectional associations with insulin restance and glycaemia in 9 10 year old children |
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