Fluid intake and incidence of renal cell carcinoma in UK women.
BACKGROUND: It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal ce...
| Auteurs principaux: | , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
2011
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| _version_ | 1826294241894072320 |
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| author | Allen, N Balkwill, A Beral, V Green, J Reeves, G |
| author_facet | Allen, N Balkwill, A Beral, V Green, J Reeves, G |
| author_sort | Allen, N |
| collection | OXFORD |
| description | BACKGROUND: It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women. METHODS: Information on beverage consumption was obtained from a questionnaire sent ∼3 years after recruitment into the Million Women Study. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index. RESULTS: After an average of 5.2 years of follow-up, 588 cases of renal cell carcinoma were identified among 779,369 women. While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for ≥ 2 vs <1 drink per day: 0.76; 95% CI: 0.61-0.96; P for trend=0.02), there was no association with total fluid intake (RR for ≥ 12 vs <7 drinks per day: 1.15; 95% CI: 0.91-1.45; P for trend=0.3) or with intakes of specific beverages. CONCLUSIONS: The apparent protective effect of alcohol on the risk of renal cell carcinoma is unlikely to be related to a high fluid intake. |
| first_indexed | 2024-03-07T03:42:36Z |
| format | Journal article |
| id | oxford-uuid:be6a1b64-83d2-4e39-adca-194e6de3be6a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:42:36Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:be6a1b64-83d2-4e39-adca-194e6de3be6a2022-03-27T05:39:14ZFluid intake and incidence of renal cell carcinoma in UK women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:be6a1b64-83d2-4e39-adca-194e6de3be6aEnglishSymplectic Elements at Oxford2011Allen, NBalkwill, ABeral, VGreen, JReeves, GBACKGROUND: It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women. METHODS: Information on beverage consumption was obtained from a questionnaire sent ∼3 years after recruitment into the Million Women Study. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for renal cell carcinoma associated with beverage consumption adjusted for age, region of residence, socioeconomic status, smoking, and body mass index. RESULTS: After an average of 5.2 years of follow-up, 588 cases of renal cell carcinoma were identified among 779,369 women. While alcohol intake was associated with a reduced risk of renal cell carcinoma (RR for ≥ 2 vs <1 drink per day: 0.76; 95% CI: 0.61-0.96; P for trend=0.02), there was no association with total fluid intake (RR for ≥ 12 vs <7 drinks per day: 1.15; 95% CI: 0.91-1.45; P for trend=0.3) or with intakes of specific beverages. CONCLUSIONS: The apparent protective effect of alcohol on the risk of renal cell carcinoma is unlikely to be related to a high fluid intake. |
| spellingShingle | Allen, N Balkwill, A Beral, V Green, J Reeves, G Fluid intake and incidence of renal cell carcinoma in UK women. |
| title | Fluid intake and incidence of renal cell carcinoma in UK women. |
| title_full | Fluid intake and incidence of renal cell carcinoma in UK women. |
| title_fullStr | Fluid intake and incidence of renal cell carcinoma in UK women. |
| title_full_unstemmed | Fluid intake and incidence of renal cell carcinoma in UK women. |
| title_short | Fluid intake and incidence of renal cell carcinoma in UK women. |
| title_sort | fluid intake and incidence of renal cell carcinoma in uk women |
| work_keys_str_mv | AT allenn fluidintakeandincidenceofrenalcellcarcinomainukwomen AT balkwilla fluidintakeandincidenceofrenalcellcarcinomainukwomen AT beralv fluidintakeandincidenceofrenalcellcarcinomainukwomen AT greenj fluidintakeandincidenceofrenalcellcarcinomainukwomen AT reevesg fluidintakeandincidenceofrenalcellcarcinomainukwomen |