Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival.

Degeneration of the neural retina is the leading cause of untreatable blindness in the developed world. Stem cell replacement therapy offers a novel strategy for retinal repair. Postmitotic photoreceptor precursors derived from the early postnatal (P) retina are able to migrate and integrate into t...

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Autori principali: West, E, Pearson, R, Duran, Y, Gonzalez-Cordero, A, Maclaren, R, Smith, A, Sowden, J, Ali, R
Natura: Journal article
Lingua:English
Pubblicazione: 2012

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