Mapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in children
The Paediatric Quality of Life Inventory (PedsQL™) questionnaire is a widely used, generic instrument designed for measuring health-related quality of life (HRQoL); however, it is not preference-based and therefore not suitable for cost-utility analysis. The Child Health Utility Index-9 Dimension (C...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer International Publishing
2017
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| _version_ | 1797092213291745280 |
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| author | Lambe, T Frew, E Ives, N Woolley, R Cummins, C Brettell, E Barsoum, E Webb, N Prednos Trial Team |
| author2 | Ray, D |
| author_facet | Ray, D Lambe, T Frew, E Ives, N Woolley, R Cummins, C Brettell, E Barsoum, E Webb, N Prednos Trial Team |
| author_sort | Lambe, T |
| collection | OXFORD |
| description | The Paediatric Quality of Life Inventory (PedsQL™) questionnaire is a widely used, generic instrument designed for measuring health-related quality of life (HRQoL); however, it is not preference-based and therefore not suitable for cost-utility analysis. The Child Health Utility Index-9 Dimension (CHU-9D), however, is a preference-based instrument that has been primarily developed to support cost-utility analysis.This paper presents a method for estimating CHU-9D index scores from responses to the PedsQL™ using data from a randomised controlled trial of prednisolone therapy for treatment of childhood corticosteroid-sensitive nephrotic syndrome.HRQoL data were collected from children at randomisation, week 16, and months 12, 18, 24, 36 and 48. Observations on children aged 5 years and older were pooled across all data collection timepoints and were then randomised into an estimation (n = 279) and validation (n = 284) sample. A number of models were developed using the estimation data before internal validation. The best model was chosen using multi-stage selection criteria.Most of the models developed accurately predicted the CHU-9D mean index score. The best performing model was a generalised linear model (mean absolute error = 0.0408; mean square error = 0.0035). The proportion of index scores deviating from the observed scores by < 0.03 was 53%.The mapping algorithm provides an empirical tool for estimating CHU-9D index scores and for conducting cost-utility analyses within clinical studies that have only collected PedsQL™ data. It is valid for children aged 5 years or older. Caution should be exercised when using this with children younger than 5 years, older adolescents (> 13 years) or patient groups with particularly poor quality of life.16645249. |
| first_indexed | 2024-03-07T03:42:57Z |
| format | Journal article |
| id | oxford-uuid:be845c97-24be-4cf0-b152-e0a2224b6bb9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:42:57Z |
| publishDate | 2017 |
| publisher | Springer International Publishing |
| record_format | dspace |
| spelling | oxford-uuid:be845c97-24be-4cf0-b152-e0a2224b6bb92022-03-27T05:40:06ZMapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in childrenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:be845c97-24be-4cf0-b152-e0a2224b6bb9EnglishSymplectic Elements at OxfordSpringer International Publishing2017Lambe, TFrew, EIves, NWoolley, RCummins, CBrettell, EBarsoum, EWebb, NPrednos Trial TeamRay, DThe Paediatric Quality of Life Inventory (PedsQL™) questionnaire is a widely used, generic instrument designed for measuring health-related quality of life (HRQoL); however, it is not preference-based and therefore not suitable for cost-utility analysis. The Child Health Utility Index-9 Dimension (CHU-9D), however, is a preference-based instrument that has been primarily developed to support cost-utility analysis.This paper presents a method for estimating CHU-9D index scores from responses to the PedsQL™ using data from a randomised controlled trial of prednisolone therapy for treatment of childhood corticosteroid-sensitive nephrotic syndrome.HRQoL data were collected from children at randomisation, week 16, and months 12, 18, 24, 36 and 48. Observations on children aged 5 years and older were pooled across all data collection timepoints and were then randomised into an estimation (n = 279) and validation (n = 284) sample. A number of models were developed using the estimation data before internal validation. The best model was chosen using multi-stage selection criteria.Most of the models developed accurately predicted the CHU-9D mean index score. The best performing model was a generalised linear model (mean absolute error = 0.0408; mean square error = 0.0035). The proportion of index scores deviating from the observed scores by < 0.03 was 53%.The mapping algorithm provides an empirical tool for estimating CHU-9D index scores and for conducting cost-utility analyses within clinical studies that have only collected PedsQL™ data. It is valid for children aged 5 years or older. Caution should be exercised when using this with children younger than 5 years, older adolescents (> 13 years) or patient groups with particularly poor quality of life.16645249. |
| spellingShingle | Lambe, T Frew, E Ives, N Woolley, R Cummins, C Brettell, E Barsoum, E Webb, N Prednos Trial Team Mapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in children |
| title | Mapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in children |
| title_full | Mapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in children |
| title_fullStr | Mapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in children |
| title_full_unstemmed | Mapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in children |
| title_short | Mapping the Paediatric Quality of Life Inventory (PedsQL™) generic core scales onto the Child Health Utility Index–9 Dimension (CHU-9D) score for economic evaluation in children |
| title_sort | mapping the paediatric quality of life inventory pedsql™ generic core scales onto the child health utility index 9 dimension chu 9d score for economic evaluation in children |
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