Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring
<p>Substantial shifts in reproductive behaviors have recently taken place in many high-income countries including earlier age at menarche, advanced age at childbearing, rising childlessness and a lower number of children. As reproduction shifts to later ages, genetic factors may become increas...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2024
|
| _version_ | 1824458728441643008 |
|---|---|
| author | Benonisdottir, S Straub, VJ Kong, A Mills, MC |
| author_facet | Benonisdottir, S Straub, VJ Kong, A Mills, MC |
| author_sort | Benonisdottir, S |
| collection | OXFORD |
| description | <p>Substantial shifts in reproductive behaviors have recently taken place in many high-income countries including earlier age at menarche, advanced age at childbearing, rising childlessness and a lower number of children. As reproduction shifts to later ages, genetic factors may become increasingly important. Although monogenic genetic effects are known, the genetics underlying human reproductive traits are complex, with both causal effects and statistical bias often confounded by socioeconomic factors. Here, we review genome-wide association studies (GWASs) of 44 reproductive traits of both female and male individuals from 2007 to early 2024, examining reproductive behavior, reproductive lifespan and aging, infertility and hormonal concentration. Using the GWAS Catalog as a basis, from 159 relevant studies, we isolate 37 genes that harbor association signals for four or more reproductive traits, more than half of which are linked to rare Mendelian disorders, including ten genes linked to reproductive-related disorders: <em>FSHB</em>, <em>MCM8</em>, <em>DNAH2</em>, <em>WNT4</em>, <em>ESR1</em>, <em>IGSF1</em>, <em>THRB</em>, <em>BRWD1</em>, <em>CYP19A1</em> and <em>PTPRF</em>. We also review the relationship of reproductive genetics to related health and behavioral traits, aging and longevity and the effect of parental age on offspring outcomes as well as reflecting on limitations, open questions and challenges in this fast-moving field.</p> |
| first_indexed | 2025-02-19T04:30:30Z |
| format | Journal article |
| id | oxford-uuid:be8bd0bd-e74c-4074-bf95-b82561d8cbc5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:30:30Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:be8bd0bd-e74c-4074-bf95-b82561d8cbc52024-12-16T13:46:07ZGenetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspringJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:be8bd0bd-e74c-4074-bf95-b82561d8cbc5EnglishSymplectic ElementsNature Research2024Benonisdottir, SStraub, VJKong, AMills, MC<p>Substantial shifts in reproductive behaviors have recently taken place in many high-income countries including earlier age at menarche, advanced age at childbearing, rising childlessness and a lower number of children. As reproduction shifts to later ages, genetic factors may become increasingly important. Although monogenic genetic effects are known, the genetics underlying human reproductive traits are complex, with both causal effects and statistical bias often confounded by socioeconomic factors. Here, we review genome-wide association studies (GWASs) of 44 reproductive traits of both female and male individuals from 2007 to early 2024, examining reproductive behavior, reproductive lifespan and aging, infertility and hormonal concentration. Using the GWAS Catalog as a basis, from 159 relevant studies, we isolate 37 genes that harbor association signals for four or more reproductive traits, more than half of which are linked to rare Mendelian disorders, including ten genes linked to reproductive-related disorders: <em>FSHB</em>, <em>MCM8</em>, <em>DNAH2</em>, <em>WNT4</em>, <em>ESR1</em>, <em>IGSF1</em>, <em>THRB</em>, <em>BRWD1</em>, <em>CYP19A1</em> and <em>PTPRF</em>. We also review the relationship of reproductive genetics to related health and behavioral traits, aging and longevity and the effect of parental age on offspring outcomes as well as reflecting on limitations, open questions and challenges in this fast-moving field.</p> |
| spellingShingle | Benonisdottir, S Straub, VJ Kong, A Mills, MC Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring |
| title | Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring |
| title_full | Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring |
| title_fullStr | Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring |
| title_full_unstemmed | Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring |
| title_short | Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring |
| title_sort | genetics of female and male reproductive traits and their relationship with health longevity and consequences for offspring |
| work_keys_str_mv | AT benonisdottirs geneticsoffemaleandmalereproductivetraitsandtheirrelationshipwithhealthlongevityandconsequencesforoffspring AT straubvj geneticsoffemaleandmalereproductivetraitsandtheirrelationshipwithhealthlongevityandconsequencesforoffspring AT konga geneticsoffemaleandmalereproductivetraitsandtheirrelationshipwithhealthlongevityandconsequencesforoffspring AT millsmc geneticsoffemaleandmalereproductivetraitsandtheirrelationshipwithhealthlongevityandconsequencesforoffspring |