The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.

The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.

Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were originally characterized as inhibitors of matrix metalloproteinases (MMPs), but their range of activities has now been fo...

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Bibliografiske detaljer
Main Authors:	Brew, K, Nagase, H
Format:	Journal article
Sprog:	English
Udgivet:	2010

Lignende værker

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors.
af: Nagase, H, et al.
Udgivet: (2003)

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1
af: Nagase, H, et al.
Udgivet: (2000)

Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors.
af: Wei, S, et al.
Udgivet: (2003)

Tissue inhibitors of metalloproteinases: evolution, structure and function.
af: Brew, K, et al.
Udgivet: (2000)

Structure and function of matrix metalloproteinases and TIMPs.
af: Nagase, H, et al.
Udgivet: (2006)

Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction.
af: Pinto, A, et al.
Udgivet: (2006)

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
af: Visse, R, et al.
Udgivet: (2003)

E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A).
af: Troeberg, L, et al.
Udgivet: (2002)

Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.
af: Nagase, H, et al.
Udgivet: (2002)

The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.
af: Zhang, J, et al.
Udgivet: (2003)

Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.
af: Itoh, Y, et al.
Udgivet: (1995)

Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface.
af: Itoh, Y, et al.
Udgivet: (1998)

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity
af: Christine Shu Mei Lee, et al.
Udgivet: (2023-12-01)

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
af: Kveiborg, M, et al.
Udgivet: (2010)

Expression of tissue inhibitors of metalloproteinase 1 (TIMP-1) in gastric cancer tissue.
af: Andrzej Kemona, et al.
Udgivet: (2010-02-01)

Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.
af: Zhao, H, et al.
Udgivet: (2004)

Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)
af: Chanalaris, A, et al.
Udgivet: (2017)

Expression of Matrix Metalloproteinases (MMPs) and Their Tissue Inhibitors (TIMPs) in Frozen Sperm of Rabbit
af: Sang Hwan Kim, et al.
Udgivet: (2019-09-01)

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
af: Scilabra, S, et al.
Udgivet: (2016)

Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor.
af: Inge Tency, et al.
Udgivet: (2012-01-01)

Relationships between Circulating Matrix Metalloproteinases, Tissue Inhibitor TIMP-2, and Renal Function in Patients with Myocarditis
af: Małgorzata Kobusiak-Prokopowicz, et al.
Udgivet: (2021-11-01)

Immunohistochemical Expression of Tissue Inhibitor of Metalloproteinase-1 (Timp-1) in Invasive Breast Carcinoma
af: Suada Kuskunović, et al.
Udgivet: (2009-05-01)

Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme.
af: Wei, S, et al.
Udgivet: (2005)

Study of the level of sputum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor metalloproteinase-1 (TIMP-1) in COPD patients
af: Sherif A. Esa, et al.
Udgivet: (2014-10-01)

Tissue Inhibitor of Matrix Metalloproteinases-1 (TIMP-1) and Pulmonary Involvement in COVID-19 Pneumonia
af: Maria Antonella Zingaropoli, et al.
Udgivet: (2023-06-01)

Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology
af: Dong Fan, et al.
Udgivet: (2020-06-01)

Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer
af: Sahar Hakamy, et al.
Udgivet: (2021-01-01)

Aggrecanases and TIMP-3 in osteoarthritis: structure, function and in vivo challenges
af: Nagase, H
Udgivet: (2009)

Upregulation of matrix metalloproteinase 9 (MMP9)/tissue inhibitor of metalloproteinase 1 (TIMP1) and MMP2/TIMP2 ratios may be involved in lipopolysaccharide-induced acute lung injury
af: Guobing Chen, et al.
Udgivet: (2020-04-01)

Complex studies on gene polymorphisms of MMP2, MMP3, MMP9 matrix metalloproteinases and TIMP1, TIMP2 tissue inhibitors of metalloproteinases in the patients with primary open-angle glaucoma
af: A. V. Shevchenko, et al.
Udgivet: (2023-04-01)

Circulating tissue inhibitor of metalloproteinases 1 (TIMP-1) at COVID-19 onset predicts severity status
af: Stefano Brusa, et al.
Udgivet: (2022-11-01)

Imbalance of tissue inhibitors of metalloproteinases (TIMP) – 1 and – 4 serum levels, in patients with inflammatory bowel disease
af: Theodoridou Aikaterini T, et al.
Udgivet: (2008-11-01)

The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer
af: Maciej Szmitkowski, et al.
Udgivet: (2012-04-01)

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Echinoderms: Structure and Possible Functions
af: Igor Yu. Dolmatov, et al.
Udgivet: (2021-09-01)

Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes.
af: Jyotica Batra, et al.
Udgivet: (2013-01-01)

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
af: Kashiwagi, M, et al.
Udgivet: (2001)

Functional Characterization of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) N- and C-Terminal Domains during Xenopus laevis Development
af: M. A. Nieuwesteeg, et al.
Udgivet: (2014-01-01)

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.
af: Seubert, B, et al.
Udgivet: (2015)

Structure and computation-guided yeast surface display for the evolution of TIMP-based matrix metalloproteinase inhibitors
af: Alireza Shoari, et al.
Udgivet: (2023-11-01)

Expression of collagenases (matrix metalloproteinase-1, -8, -13) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in naturally occurring bovine cutaneous fibropapillomas
af: Florentina Daraban Bocaneti, et al.
Udgivet: (2023-01-01)