Gene loops enhance transcriptional directionality

Eukaryotic genomes are extensively transcribed, forming both messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). ncRNAs made by RNA polymerase II often initiate from bidirectional promoters (nucleosome-depleted chromatin) that synthesize mRNA and ncRNA in opposite directions. We demonstrate that, by...

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Príomhchruthaitheoirí: Tan-Wong, S, Zaugg, J, Camblong, J, Xu, Z, Zhang, D, Mischo, H, Ansari, A, Luscombe, N, Steinmetz, L, Proudfoot, N
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: American Association for the Advancement of Science 2012