A novel role for BRCA1 in regulating breast cancer cell spreading and motility.
BRCA1 C-terminal (BRCT) domains in BRCA1 are essential for tumor suppressor function, though the underlying mechanisms remain unclear. We identified ezrin, radixin, and moesin as BRCA1 BRCT domain-interacting proteins. Ezrin-radixin-moesin (ERM) and F-actin colocalized with BRCA1 at the plasma membr...
Main Authors: | Coene, E, Gadelha, C, White, N, Malhas, A, Thomas, B, Shaw, M, Vaux, D |
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Format: | Journal article |
Language: | English |
Published: |
2011
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