Paradoxical facilitation after depotentiation protocol can precede dyskinesia onset in early Parkinson's disease

Loss of dopamine, a key modulator of synaptic signalling, and subsequent pulsatile non-physiological levodopa replacement is believed to underlie altered neuroplasticity in Parkinson's disease (PD). Animal models suggest that maladaptive plasticity (e.g. deficient depotentiation at corticostria...

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Príomhchruthaitheoirí: Lago-Rodriguez, A, Ponzo, V, Jenkinson, N, Benitez-Rivero, S, Del-Olmo, M, Hu, M, Koch, G, Cheeran, B
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Springer Verlag 2016