Critical residues for structure and catalysis in short-chain dehydrogenases/reductases.

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases.

Short-chain dehydrogenases/reductases form a large, evolutionarily old family of NAD(P)(H)-dependent enzymes with over 60 genes found in the human genome. Despite low levels of sequence identity (often 10-30%), the three-dimensional structures display a highly similar alpha/beta folding pattern. We...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Filling, C, Berndt, K, Benach, J, Knapp, S, Prozorovski, T, Nordling, E, Ladenstein, R, Jörnvall, H, Oppermann, U
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	2002

Նմանատիպ նյութեր

Structural role of conserved Asn179 in the short-chain dehydrogenase/reductase scaffold.
‌: Filling, C, և այլն
Հրապարակվել է: (2001)

Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.
‌: Oppermann, U, և այլն
Հրապարակվել է: (1997)

Short-chain dehydrogenases/reductases (SDR): the 2002 update.
‌: Oppermann, U, և այլն
Հրապարակվել է: (2003)

Short-chain dehydrogenases/reductases (SDRs).
‌: Kallberg, Y, և այլն
Հրապարակվել է: (2002)

Structure-function relationships of 3 beta-hydroxysteroid dehydrogenases involved in bile acid metabolism.
‌: Filling, C, և այլն
Հրապարակվել է: (1999)

Structure of bacterial 3beta/17beta-hydroxysteroid dehydrogenase at 1.2 A resolution: a model for multiple steroid recognition.
‌: Benach, J, և այլն
Հրապարակվել է: (2002)

Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).
‌: Persson, B, և այլն
Հրապարակվել է: (2003)

Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities.
‌: Wu, X, և այլն
Հրապարակվել է: (2007)

Crystallization and crystal packing of recombinant 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni ATTC 11996.
‌: Benach, J, և այլն
Հրապարակվել է: (1996)

Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency.
‌: Filling, C, և այլն
Հրապարակվել է: (2008)

Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes.
‌: Kallberg, Y, և այլն
Հրապարակվել է: (2002)

Structure-function relationships of SDR hydroxysteroid dehydrogenases.
‌: Oppermann, U, և այլն
Հրապարակվել է: (1997)

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
‌: Kavanagh, K, և այլն
Հրապարակվել է: (2008)

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
‌: Kavanagh, K, և այլն
Հրապարակվել է: (2008)

Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.
‌: Shafqat, N, և այլն
Հրապարակվել է: (2006)

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
‌: Persson, B, և այլն
Հրապարակվել է: (2009)

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
‌: Persson, B, և այլն
Հրապարակվել է: (2009)

The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary
‌: Bray, J, և այլն
Հրապարակվել է: (2009)

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models
‌: Kallberg, Y, և այլն
Հրապարակվել է: (2010)

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models.
‌: Kallberg, Y, և այլն
Հրապարակվել է: (2010)

The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary.
‌: Bray, J, և այլն
Հրապարակվել է: (2009)

Molecular cloning and sequencing of mouse hepatic 11 beta-hydroxysteroid dehydrogenase/carbonyl reductase. A member of the short chain dehydrogenase superfamily.
‌: Maser, E, և այլն
Հրապարակվել է: (1995)

Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.
‌: Nordling, E, և այլն
Հրապարակվել է: (2001)

Human liver class I alcohol dehydrogenase gammagamma isozyme: the sole cytosolic 3beta-hydroxysteroid dehydrogenase of iso bile acids.
‌: Marschall, H, և այլն
Հրապարակվել է: (2000)

Forms and functions of human SDR enzymes.
‌: Oppermann, U, և այլն
Հրապարակվել է: (2001)

Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement
‌: Persson Bengt, և այլն
Հրապարակվել է: (2010-10-01)

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase
‌: Guo, K, և այլն
Հրապարակվել է: (2006)

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.
‌: Guo, K, և այլն
Հրապարակվել է: (2006)

Isolation and structure of repressor-like proteins from the archaeon Sulfolobus solfataricus. Co-purification of RNase A with Sso7c.
‌: Oppermann, U, և այլն
Հրապարակվել է: (1998)

Enantiocomplementary Yarrowia lipolytica Oxidoreductases: Alcohol Dehydrogenase 2 and Short Chain Dehydrogenase/Reductase
‌: Margit Winkler, և այլն
Հրապարակվել է: (2013-08-01)

An ethanol-inducible MDR ethanol dehydrogenase/acetaldehyde reductase in Escherichia coli: structural and enzymatic relationships to the eukaryotic protein forms.
‌: Shafqat, J, և այլն
Հրապարակվել է: (1999)

Bioinformatic analysis of short-chain dehydrogenase/reductase proteins in plant peroxisomes
‌: Yuchan Zhang, և այլն
Հրապարակվել է: (2023-06-01)

Multiple short‐chain dehydrogenases/reductases are regulated in pathological cardiac hypertrophy
‌: Elise Roussel, և այլն
Հրապարակվել է: (2018-10-01)

The characterization of a short chain dehydrogenase/reductase (SDRx) in Comamonas testosteroni
‌: Chuanzhi Liu, և այլն
Հրապարակվել է: (2020-01-01)

Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD.
‌: Shafqat, N, և այլն
Հրապարակվել է: (2003)

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
‌: Oppermann, U, և այլն
Հրապարակվել է: (1997)

Lack of quinone reductase activity suggests that amyloid-beta peptide/ERAB induced lipid peroxidation is not directly related to production of reactive oxygen species by redoxcycling.
‌: Salim, S, և այլն
Հրապարակվել է: (2000)

Delineating Substrate Diversity of Disparate Short-Chain Dehydrogenase Reductase from Debaryomyces hansenii.
‌: Arindam Ghatak, և այլն
Հրապարակվել է: (2017-01-01)

Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics.
‌: Hult, M, և այլն
Հրապարակվել է: (1998)

Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase.
‌: Oppermann, U, և այլն
Հրապարակվել է: (1995)