Tetrahydrofuran alpha-azido esters: Precursors of anomeric alpha-amino acid monomers via radical bromination

A general route for the synthesis of tetrahydrofuran α-azido esters as the equivalent of monomeric furanose anomeric α-amino acids is described. Highly selective radical bromination of a range of suitably protected carbohydrate C-glycosyl derivatives affords bromo-esters which undergo efficient disp...

Полное описание

Библиографические подробности
Главные авторы: Smith, M, Long, D, Martin, A, Campbell, N, Bleriot, Y, Fleet, G
Формат: Journal article
Язык:English
Опубликовано: 1999
Описание
Итог:A general route for the synthesis of tetrahydrofuran α-azido esters as the equivalent of monomeric furanose anomeric α-amino acids is described. Highly selective radical bromination of a range of suitably protected carbohydrate C-glycosyl derivatives affords bromo-esters which undergo efficient displacement by azide to give anomeric α-amino acid derivatives.