GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretion in pancreatic islets. Here, we examined the mech...

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Bibliographic Details
Main Authors: Zaccolo, M, Shigeto, M, Ramracheya, R, Tarasov, A, Cha, C, Chibalina, M, Hastoy, B, Philippaert, K, Reinbothe, T, Rorsman, N, Salehi, A, Sones, W, Vergari, E, Weston, C, Gorelik, J, Katsura, M, Nikolaev, V, Vennekens, R, Galione, A, Johnson, P, Kaku, K, Ladds, G, Rorsman, P
Format: Journal article
Language:English
Published: American Society for Clinical Investigation 2015

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