Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema.
BACKGROUND: The role of the innate immune protein mannose-binding lectin (MBL) in host defence against severe respiratory infection remains controversial. Thoracic empyema is a suppurative lung infection that arises as a major complication of pneumonia and is associated with a significant mortality...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2010
|
| _version_ | 1826294403007774720 |
|---|---|
| author | Chapman, S Vannberg, F Khor, C Rautanen, A Maskell, N Davies, C Moore, C Day, N Crook, D Davies, R Hill, A |
| author_facet | Chapman, S Vannberg, F Khor, C Rautanen, A Maskell, N Davies, C Moore, C Day, N Crook, D Davies, R Hill, A |
| author_sort | Chapman, S |
| collection | OXFORD |
| description | BACKGROUND: The role of the innate immune protein mannose-binding lectin (MBL) in host defence against severe respiratory infection remains controversial. Thoracic empyema is a suppurative lung infection that arises as a major complication of pneumonia and is associated with a significant mortality. Although the pathogenesis of thoracic empyema is poorly understood, genetic susceptibility loci for this condition have recently been identified. The possible role of MBL genotypic deficiency in susceptibility to thoracic empyema has not previously been reported. METHODS: To investigate this further we compared the frequencies of the six functional MBL polymorphisms in 170 European individuals with thoracic empyema and 225 healthy control individuals. RESULTS: No overall association was observed between MBL genotypic deficiency and susceptibility to thoracic empyema (2 x 2 Chi square = 0.02, P = 0.87). Furthermore, no association was seen between MBL deficiency and susceptibility to the Gram-positive or pneumococcal empyema subgroups. MBL genotypic deficiency did not associate with progression to death or requirement for surgery. CONCLUSIONS: Our results suggest that MBL genotypic deficiency does not associate with susceptibility to thoracic empyema in humans. |
| first_indexed | 2024-03-07T03:45:05Z |
| format | Journal article |
| id | oxford-uuid:bf330a23-58e8-4867-8d45-b76753f4c5ef |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:45:05Z |
| publishDate | 2010 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:bf330a23-58e8-4867-8d45-b76753f4c5ef2022-03-27T05:45:40ZMannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bf330a23-58e8-4867-8d45-b76753f4c5efEnglishSymplectic Elements at OxfordBioMed Central2010Chapman, SVannberg, FKhor, CRautanen, AMaskell, NDavies, CMoore, CDay, NCrook, DDavies, RHill, A BACKGROUND: The role of the innate immune protein mannose-binding lectin (MBL) in host defence against severe respiratory infection remains controversial. Thoracic empyema is a suppurative lung infection that arises as a major complication of pneumonia and is associated with a significant mortality. Although the pathogenesis of thoracic empyema is poorly understood, genetic susceptibility loci for this condition have recently been identified. The possible role of MBL genotypic deficiency in susceptibility to thoracic empyema has not previously been reported. METHODS: To investigate this further we compared the frequencies of the six functional MBL polymorphisms in 170 European individuals with thoracic empyema and 225 healthy control individuals. RESULTS: No overall association was observed between MBL genotypic deficiency and susceptibility to thoracic empyema (2 x 2 Chi square = 0.02, P = 0.87). Furthermore, no association was seen between MBL deficiency and susceptibility to the Gram-positive or pneumococcal empyema subgroups. MBL genotypic deficiency did not associate with progression to death or requirement for surgery. CONCLUSIONS: Our results suggest that MBL genotypic deficiency does not associate with susceptibility to thoracic empyema in humans. |
| spellingShingle | Chapman, S Vannberg, F Khor, C Rautanen, A Maskell, N Davies, C Moore, C Day, N Crook, D Davies, R Hill, A Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. |
| title | Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. |
| title_full | Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. |
| title_fullStr | Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. |
| title_full_unstemmed | Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. |
| title_short | Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. |
| title_sort | mannose binding lectin genotypes lack of association with susceptibility to thoracic empyema |
| work_keys_str_mv | AT chapmans mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT vannbergf mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT khorc mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT rautanena mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT maskelln mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT daviesc mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT moorec mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT dayn mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT crookd mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT daviesr mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema AT hilla mannosebindinglectingenotypeslackofassociationwithsusceptibilitytothoracicempyema |