A comparison of cardiac (31)P MRS at 1.5 and 3 T.
(31)P MRS was evaluated on normal volunteers at 1.5 and 3 T, and the signal-to-noise ratio (SNR) of the two field strengths was calculated. The in vivo spin-lattice, T(1), relaxation times for PCr and gamma-ATP, which are essential for correcting for the effects of radiofrequency saturation on the P...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797092378987724800 |
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| author | Tyler, D Hudsmith, L Clarke, K Neubauer, S Robson, M |
| author_facet | Tyler, D Hudsmith, L Clarke, K Neubauer, S Robson, M |
| author_sort | Tyler, D |
| collection | OXFORD |
| description | (31)P MRS was evaluated on normal volunteers at 1.5 and 3 T, and the signal-to-noise ratio (SNR) of the two field strengths was calculated. The in vivo spin-lattice, T(1), relaxation times for PCr and gamma-ATP, which are essential for correcting for the effects of radiofrequency saturation on the PCr/ATP ratio, were determined at 3 T. The T(1) values for six volunteers were 3.8 +/- 0.7 s for PCr (mean +/- SD) and 2.4 +/- 1.1 s for gamma-ATP, which are similar to reported values at 1.5 T, allowing us to use protocols developed at 1.5 T at the new clinical field strength of 3 T. Direct comparison between 1.5 T and 3 T in the same 10 subjects, using coils of identical geometry and identical pulse sequences gave a mean SNR for PCr at 3 T which was 206 +/- 94% of that at 1.5 T. The linewidth for PCr increased from 13 +/- 6 Hz at 1.5 T to 22 +/- 12 Hz at 3 T. The coefficient of variation in the measurement of PCr/ATP, based on the Cramer-Rao lower bounds, was reduced from 32 +/- 25% at 1.5 T to 18 +/- 13% at 3 T. Thus, (31)P MRS at 3 T is greatly improved by the increase in SNR compared with acquisitions at 1.5 T because of the higher field strength. |
| first_indexed | 2024-03-07T03:45:09Z |
| format | Journal article |
| id | oxford-uuid:bf373470-b79d-4d3e-87ac-0af8978ba734 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:45:09Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:bf373470-b79d-4d3e-87ac-0af8978ba7342022-03-27T05:45:45ZA comparison of cardiac (31)P MRS at 1.5 and 3 T.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bf373470-b79d-4d3e-87ac-0af8978ba734EnglishSymplectic Elements at Oxford2008Tyler, DHudsmith, LClarke, KNeubauer, SRobson, M(31)P MRS was evaluated on normal volunteers at 1.5 and 3 T, and the signal-to-noise ratio (SNR) of the two field strengths was calculated. The in vivo spin-lattice, T(1), relaxation times for PCr and gamma-ATP, which are essential for correcting for the effects of radiofrequency saturation on the PCr/ATP ratio, were determined at 3 T. The T(1) values for six volunteers were 3.8 +/- 0.7 s for PCr (mean +/- SD) and 2.4 +/- 1.1 s for gamma-ATP, which are similar to reported values at 1.5 T, allowing us to use protocols developed at 1.5 T at the new clinical field strength of 3 T. Direct comparison between 1.5 T and 3 T in the same 10 subjects, using coils of identical geometry and identical pulse sequences gave a mean SNR for PCr at 3 T which was 206 +/- 94% of that at 1.5 T. The linewidth for PCr increased from 13 +/- 6 Hz at 1.5 T to 22 +/- 12 Hz at 3 T. The coefficient of variation in the measurement of PCr/ATP, based on the Cramer-Rao lower bounds, was reduced from 32 +/- 25% at 1.5 T to 18 +/- 13% at 3 T. Thus, (31)P MRS at 3 T is greatly improved by the increase in SNR compared with acquisitions at 1.5 T because of the higher field strength. |
| spellingShingle | Tyler, D Hudsmith, L Clarke, K Neubauer, S Robson, M A comparison of cardiac (31)P MRS at 1.5 and 3 T. |
| title | A comparison of cardiac (31)P MRS at 1.5 and 3 T. |
| title_full | A comparison of cardiac (31)P MRS at 1.5 and 3 T. |
| title_fullStr | A comparison of cardiac (31)P MRS at 1.5 and 3 T. |
| title_full_unstemmed | A comparison of cardiac (31)P MRS at 1.5 and 3 T. |
| title_short | A comparison of cardiac (31)P MRS at 1.5 and 3 T. |
| title_sort | comparison of cardiac 31 p mrs at 1 5 and 3 t |
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