NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.

Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional homeostatic deviations that result from loss...

Full description

Bibliographic Details
Main Authors:	Rojo, A, Pajares, M, Rada, P, Nuñez, A, Nevado-Holgado, A, Killik, R, Van Leuven, F, Ribe, E, Lovestone, S, Yamamoto, M, Cuadrado, A
Format:	Journal article
Language:	English
Published:	Elsevier 2017

Similar Items

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
by: Ana I. Rojo, et al.
Published: (2017-10-01)

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy
by: Ana I. Rojo, et al.
Published: (2018-09-01)

Determining the molecular pathways underlying the protective effect of non-steroidal anti-inflammatory drugs for Alzheimer's disease: A bioinformatics approach
by: Nevado-Holgado, A, et al.
Published: (2016)

Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease
by: Winchester, L, et al.
Published: (2018)

Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach
by: Alejo J Nevado-Holgado, et al.
Published: (2017-01-01)

Insulin signalling in Alzheimer's disease and diabetes: from epidemiology to molecular links.
by: Ribe, E, et al.
Published: (2016)

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
by: Marta Pajares, et al.
Published: (2017-04-01)

The influence of insulin resistance on CSF and plasma biomarkers of Alzheimer’s pathology
by: Westwood, S, et al.
Published: (2017)

Genetic and real-world clinical data, combined with empirical validation, nominate Jak-Stat signaling as a target for Alzheimer’s disease therapeutic development
by: Nevado-Holgado, A, et al.
Published: (2019)

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease
by: Yun Yang, et al.
Published: (2022-01-01)

Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease
by: Laura M. Winchester, et al.
Published: (2018-06-01)

TYPE TWO DIABETES WORSENS COGNITIVE IMPAIRMENT AND MODIFIES TAU PHOSPHORYLATION PATTERNS IN A MODEL OF ALZHEIMER’S DISEASE
by: Maria Vargas-Soria, et al.
Published: (2023-10-01)

Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in mice
by: Ana Martín-Sánchez, et al.
Published: (2021-04-01)

Clusterin in Alzheimer’s disease: mechanisms, genetics, and lessons from other pathologies
by: Foster, E, et al.
Published: (2019)

Study on early cognitive function in transgenic APP/PS-1/tau mice model of Alzheimer's disease
by: Li WANG, et al.
Published: (2015-05-01)

Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer’s Disease Therapeutic Development
by: Alejo J. Nevado-Holgado, et al.
Published: (2019-05-01)

Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer’s Disease
by: Francisca Villavicencio-Tejo, et al.
Published: (2022-03-01)

BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
by: Xiaoqing Zhang, et al.
Published: (2021-03-01)

The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
by: Alvina W M To, et al.
Published: (2011-02-01)

Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics
by: Kocagoncu, E, et al.
Published: (2020)

Imaging Aβ and tau in early stage Alzheimer’s disease with [18F]AV45 and [18F]AV1451
by: Firouzian, A, et al.
Published: (2018)

Commonly prescribed drugs associate with cognitive function: a cross-sectional study in UK Biobank
by: Nevado-Holgado, A, et al.
Published: (2016)

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease
by: Yang-Ping Shentu, et al.
Published: (2018-07-01)

Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling
by: Thomas Filip, et al.
Published: (2021-10-01)

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
by: Elena M. Ribé, et al.
Published: (2005-12-01)

Role of Tau and NRF2 in oxidative stress responses
by: Ameyaw, B
Published: (2024)

Role of NRF2 in Pathogenesis of Alzheimer’s Disease
by: Ching-Tung Chu, et al.
Published: (2024-12-01)

Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.
by: Kaushik Ghosal, et al.
Published: (2016-01-01)

Plasma tau complements CSF tau and P‐tau in the diagnosis of Alzheimer's disease
by: Silvia Fossati, et al.
Published: (2019-12-01)

Testosterone deficiency worsens mitochondrial dysfunction in APP/PS1 mice
by: Tianyun Zhang, et al.
Published: (2024-05-01)

Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood
by: Marilena M. Bourdakou, et al.
Published: (2023-11-01)

Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
by: Rebecca M. Fleeman, et al.
Published: (2021-03-01)

Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease
by: Laura D. Owlett, et al.
Published: (2022-02-01)

Worsening hearing was associated with higher β-amyloid and tau burden in age-related hearing loss
by: Mengmeng Zheng, et al.
Published: (2022-06-01)

Tau kinetics in Alzheimer's disease
by: Daniel B. Hier, et al.
Published: (2022-11-01)

Tau Ubiquitination in Alzheimer's Disease
by: Longfei Li, et al.
Published: (2022-02-01)

Toxic tau: structural origins of tau aggregation in Alzheimer's disease
by: Abdullah Al Mamun, et al.
Published: (2020-01-01)

A decade of blood biomarkers for Alzheimer's disease research: an evolving field, improving study designs, and the challenge of replication
by: Shi, L, et al.
Published: (2018)

Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?
by: Mirjam Brackhan, et al.
Published: (2023-08-01)

High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow
by: Oliver Bracko, et al.
Published: (2020-06-01)