The mutation rate and cancer.
The selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is therefore a form of evolution at the somatic level, in which the population is comprised of individual cells within the tumor. Models of tumorigenesis have considered the relative importance of mutation and sel...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1826294424835981312 |
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| author | Tomlinson, I Novelli, MR Bodmer, W |
| author_facet | Tomlinson, I Novelli, MR Bodmer, W |
| author_sort | Tomlinson, I |
| collection | OXFORD |
| description | The selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is therefore a form of evolution at the somatic level, in which the population is comprised of individual cells within the tumor. Models of tumorigenesis have considered the relative importance of mutation and selection. We show that selection is more important than an increased mutation rate in the growth of a tumor. Some cancers may acquire a "mutator phenotype," probably leading to faster growth, but mutator phenotypes are not necessary for carcinogenesis. |
| first_indexed | 2024-03-07T03:45:25Z |
| format | Journal article |
| id | oxford-uuid:bf4df8bc-8307-4f7e-b070-38dc146e5947 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:45:25Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:bf4df8bc-8307-4f7e-b070-38dc146e59472022-03-27T05:46:24ZThe mutation rate and cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bf4df8bc-8307-4f7e-b070-38dc146e5947EnglishSymplectic Elements at Oxford1996Tomlinson, INovelli, MRBodmer, WThe selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is therefore a form of evolution at the somatic level, in which the population is comprised of individual cells within the tumor. Models of tumorigenesis have considered the relative importance of mutation and selection. We show that selection is more important than an increased mutation rate in the growth of a tumor. Some cancers may acquire a "mutator phenotype," probably leading to faster growth, but mutator phenotypes are not necessary for carcinogenesis. |
| spellingShingle | Tomlinson, I Novelli, MR Bodmer, W The mutation rate and cancer. |
| title | The mutation rate and cancer. |
| title_full | The mutation rate and cancer. |
| title_fullStr | The mutation rate and cancer. |
| title_full_unstemmed | The mutation rate and cancer. |
| title_short | The mutation rate and cancer. |
| title_sort | mutation rate and cancer |
| work_keys_str_mv | AT tomlinsoni themutationrateandcancer AT novellimr themutationrateandcancer AT bodmerw themutationrateandcancer AT tomlinsoni mutationrateandcancer AT novellimr mutationrateandcancer AT bodmerw mutationrateandcancer |