Glucose-sensing mechanisms in pancreatic beta-cells.
The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or...
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| Fformat: | Conference item |
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2005
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| _version_ | 1826294428958982144 |
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| author | MacDonald, P Joseph, J Rorsman, P |
| author_facet | MacDonald, P Joseph, J Rorsman, P |
| author_sort | MacDonald, P |
| collection | OXFORD |
| description | The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion. |
| first_indexed | 2024-03-07T03:45:29Z |
| format | Conference item |
| id | oxford-uuid:bf52eb19-ddca-417a-83fb-a27ae5033a23 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:45:29Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:bf52eb19-ddca-417a-83fb-a27ae5033a232022-03-27T05:46:35ZGlucose-sensing mechanisms in pancreatic beta-cells.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:bf52eb19-ddca-417a-83fb-a27ae5033a23Symplectic Elements at Oxford2005MacDonald, PJoseph, JRorsman, PThe appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion. |
| spellingShingle | MacDonald, P Joseph, J Rorsman, P Glucose-sensing mechanisms in pancreatic beta-cells. |
| title | Glucose-sensing mechanisms in pancreatic beta-cells. |
| title_full | Glucose-sensing mechanisms in pancreatic beta-cells. |
| title_fullStr | Glucose-sensing mechanisms in pancreatic beta-cells. |
| title_full_unstemmed | Glucose-sensing mechanisms in pancreatic beta-cells. |
| title_short | Glucose-sensing mechanisms in pancreatic beta-cells. |
| title_sort | glucose sensing mechanisms in pancreatic beta cells |
| work_keys_str_mv | AT macdonaldp glucosesensingmechanismsinpancreaticbetacells AT josephj glucosesensingmechanismsinpancreaticbetacells AT rorsmanp glucosesensingmechanismsinpancreaticbetacells |