Glucose-sensing mechanisms in pancreatic beta-cells.

Glucose-sensing mechanisms in pancreatic beta-cells.

The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	MacDonald, P, Joseph, J, Rorsman, P
Format:	Conference item
Udgivet:	2005

Lignende værker

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.
af: MacDonald, P, et al.
Udgivet: (2006)

GLUCOSE-INDUCED RETENTION OF MANGANESE IN PANCREATIC BETA-CELLS
af: Rorsman, P
Udgivet: (1982)

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.
af: MacDonald, P, et al.
Udgivet: (2007)

Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells.
af: Rorsman, P
Udgivet: (1982)

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.
af: Patrick E MacDonald, et al.
Udgivet: (2006-02-01)

Manganese accumulation in pancreatic beta-cells and its stimulation by glucose.
af: Rorsman, P, et al.
Udgivet: (1982)

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.
af: MacDonald, P, et al.
Udgivet: (2006)

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells
af: Macdonald, P, et al.
Udgivet: (2006)

Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.
af: Rorsman, P, et al.
Udgivet: (1985)

Electrophysiology of the pancreatic beta-cell.
af: Ashcroft, F, et al.
Udgivet: (1989)

Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.
af: Smith, P, et al.
Udgivet: (1989)

EVIDENCE THAT GLUCOSE-INDUCED DEPOLARIZATION IN THE PANCREATIC BETA-CELLS INVOLVES THE CLOSURE OF AN ATP-DEPENDENT K+-CHANNEL
af: Rorsman, P, et al.
Udgivet: (1985)

Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells.
af: Rorsman, P, et al.
Udgivet: (1984)

Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation.
af: Kanno, T, et al.
Udgivet: (2002)

Multivesicular exocytosis in rat pancreatic beta cells
af: Hoppa, M, et al.
Udgivet: (2011)

Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.
af: Hellman, B, et al.
Udgivet: (1980)

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
af: Zehetner, J, et al.
Udgivet: (2008)

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.
af: Braun, M, et al.
Udgivet: (2007)

Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic beta-cells.
af: Arkhammar, P, et al.
Udgivet: (1986)

Insulin granule dynamics in pancreatic beta cells.
af: Rorsman, P, et al.
Udgivet: (2003)

Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells.
af: Smith, P, et al.
Udgivet: (1990)

Insulin secretion: Function and therapy of pancreatic beta-cells in diabetes
af: Rorsman, P
Udgivet: (2005)

The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint.
af: Rorsman, P
Udgivet: (1997)

DIRECT EVIDENCE THAT GLUCOSE BOTH REDUCES AND INCREASES CYTOSOLIC FREE CA-2+ IN MOUSE PANCREATIC BETA-CELLS
af: Rorsman, P, et al.
Udgivet: (1984)

Expression of GABA(A) receptor Cl- channels and glucose-dependent GABA release in human pancreatic islets
af: Braun, M, et al.
Udgivet: (2006)

Exocytotic properties of human pancreatic beta-cells.
af: Braun, M, et al.
Udgivet: (2009)

The interaction between manganese and calcium fluxes in pancreatic beta-cells.
af: Rorsman, P, et al.
Udgivet: (1983)

KATP channel-dependent regulation of glucagon release from mouse and human pancreatic alpha-cells
af: Rorsman, P, et al.
Udgivet: (2007)

Stimulus-secretion coupling in pancreatic beta cells.
af: Ashcroft, F, et al.
Udgivet: (1994)

Multivesicular exocytosis in rat pancreatic beta cells.
af: Hoppa, M, et al.
Udgivet: (2012)

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.
af: Rorsman, P, et al.
Udgivet: (1989)

The dual action of glucose on the cytosolic Ca2+ activity in pancreatic beta-cells. Demonstration of an inhibitory effect of glucose on insulin release in the mouse and man.
af: Hellman, B, et al.
Udgivet: (1985)

SINGLE CALCIUM-CHANNEL ACTIVITY IN MOUSE PANCREATIC BETA-CELLS
af: Ashcroft, F, et al.
Udgivet: (1989)

Single calcium channel activity in mouse pancreatic beta-cells.
af: Ashcroft, F, et al.
Udgivet: (1989)

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.
af: Hanna, S, et al.
Udgivet: (2009)

ATP-dependence of exocytosis in mouse pancreatic beta-cells
af: Eliasson, L, et al.
Udgivet: (1997)

Regulated exocytosis of GABA from pancreatic beta-cells
af: Braun, M, et al.
Udgivet: (2004)

Glucose-induced increase in cytoplasmic pH in pancreatic beta-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.
af: Juntti-Berggren, L, et al.
Udgivet: (1991)

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.
af: MacDonald, P, et al.
Udgivet: (2005)

THE ROLE OF ION CHANNELS IN STIMULUS-SECRETION COUPLING IN PANCREATIC BETA-CELLS
af: Ashcroft, F, et al.
Udgivet: (1990)