Diabetes reduces vascular tetrahydrobiopterin levels by oxidation: Insights from a GTPCH-transgenic mouse model

Diabetes reduces vascular tetrahydrobiopterin levels by oxidation: Insights from a GTPCH-transgenic mouse model

Bibliografiska uppgifter
Huvudupphovsmän:	Alp, N, Mussa, S, Goh, N, Cai, S, Channon, K
Materialtyp:	Conference item
Publicerad:	2003

Liknande verk

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
av: Alp, N, et al.
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Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
av: Alp, N, et al.
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Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
av: Cai, S, et al.
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Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I over-expression
av: Alp, N, et al.
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Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
av: Alp, N, et al.
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Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
av: Alp, N, et al.
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Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
av: Alp, N, et al.
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Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
av: Alp, N, et al.
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Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
av: Cai, S, et al.
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Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
av: Bendall, J, et al.
Publicerad: (2004)

huGTPCH Expressing S plus S-Antilles Mice Have Reduced Gardos Channel Activity, Endothelin-1 Expression, and Endothelin Receptor A and B Expression, While Total Biopterin and Percent Tetrahydrobiopterin Are Increased
av: Romero, JR, et al.
Publicerad: (2008)

The % tetrahydrobiopterin (BH4) and serine 1177 phosphorylation 19 reduced in sickle transgenic mice
av: Chen, Q, et al.
Publicerad: (2007)

GTPCH I overexpression decreases atherosclerotic lesion formation in apolipoprotein E-deficient/eNOS transgenic mice
av: Takaya, T, et al.
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Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
av: Channon, K
Publicerad: (2004)

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
av: Schmidt, T, et al.
Publicerad: (2010)

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
av: Khoo, J, et al.
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Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
av: Rinze, R, et al.
Publicerad: (2008)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
av: Alp, N, et al.
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Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
av: Ali, Z, et al.
Publicerad: (2007)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
av: Alp, N, et al.
Publicerad: (2003)

Correction of tetrahydrobiopterin deficiency - Implications for dopa responsive dystonia and other inherited disorders of tetrahydrobiopterin metabolism
av: Heales, S, et al.
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The relative contributions of cardiomyocytes versus endothelial cells to cardiac BH4 production; studies in novel cardiomyocyte- and endothelial-specific GTPCH I-deficient mice
av: Bendall, J, et al.
Publicerad: (2012)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
av: Ali, Z, et al.
Publicerad: (2011)

Regulation of eNOS function by tetrahydrobiopterin in vascular disease
av: Channon, K
Publicerad: (2004)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
av: Khoo, J, et al.
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Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
av: Khoo, J, et al.
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Tetrahydrobiopterin and nitric oxide synthase recouplers
av: Channon, KM
Publicerad: (2020)

Dihydrofolate reductase is required to maintain endothelial nitric oxide synthase coupling in vivo: Insights from methotrexate-treated BH4 deficient and GTPCH overexpressing mice
av: Crabtree, M, et al.
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Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
av: Khoo, J, et al.
Publicerad: (2005)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
av: Crabtree, M, et al.
Publicerad: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
av: Crabtree, M, et al.
Publicerad: (2011)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
av: Channon, K
Publicerad: (2012)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
av: Ali, Z, et al.
Publicerad: (2005)

Low-dose Tetrahydrobiopterin Supplementation Reduces Atherosclerosis Progression in Apolipoprotein E-Knockout Mice via Effects on Vascular T cell Infiltration
av: Schmidt, T, et al.
Publicerad: (2009)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
av: Khoo, J, et al.
Publicerad: (2004)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
av: Bendall, J, et al.
Publicerad: (2005)

Tetrahydrobiopterin regulates vagal control of heart rate
av: Adlam, D, et al.
Publicerad: (2005)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
av: Khoo, J, et al.
Publicerad: (2004)

Tetrahydrobiopterin in the vascular system
av: Walter Roland, et al.
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Tetrahydrobiopterin: coupling nitric oxide and redox signalling in cardiovascular disease
av: Channon, K
Publicerad: (2012)