Genetics of multiple sclerosis.
Multiple Sclerosis (MS) is a common chronic central nervous system disease in young adults. Relative familial risk appears to be determined largely by genes while population risk is strongly influenced by environmental factors. This is supported by genetic epidemiological studies which also suggest...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1997
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| _version_ | 1797092419671425024 |
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| author | Dyment, D Sadovnick, A Ebers, G Sadnovich, A |
| author_facet | Dyment, D Sadovnick, A Ebers, G Sadnovich, A |
| author_sort | Dyment, D |
| collection | OXFORD |
| description | Multiple Sclerosis (MS) is a common chronic central nervous system disease in young adults. Relative familial risk appears to be determined largely by genes while population risk is strongly influenced by environmental factors. This is supported by genetic epidemiological studies which also suggest an oligogenic inheritance of susceptibility. The HLA DRB1*1501, DQA1*0102, DQB1 0602 haplotype is associated with the disease but HLA contributes only modestly to overall susceptibility. The results of three genomic searches are concordant with the genetic epidemiology and imply a number of genes with interacting effects will be found. Importantly, no single region has been identified with a major influence on familial risk. |
| first_indexed | 2024-03-07T03:45:39Z |
| format | Journal article |
| id | oxford-uuid:bf614799-dff2-49fa-9e6b-7af04817c0b5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:45:39Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:bf614799-dff2-49fa-9e6b-7af04817c0b52022-03-27T05:46:56ZGenetics of multiple sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bf614799-dff2-49fa-9e6b-7af04817c0b5EnglishSymplectic Elements at Oxford1997Dyment, DSadovnick, AEbers, GSadnovich, AMultiple Sclerosis (MS) is a common chronic central nervous system disease in young adults. Relative familial risk appears to be determined largely by genes while population risk is strongly influenced by environmental factors. This is supported by genetic epidemiological studies which also suggest an oligogenic inheritance of susceptibility. The HLA DRB1*1501, DQA1*0102, DQB1 0602 haplotype is associated with the disease but HLA contributes only modestly to overall susceptibility. The results of three genomic searches are concordant with the genetic epidemiology and imply a number of genes with interacting effects will be found. Importantly, no single region has been identified with a major influence on familial risk. |
| spellingShingle | Dyment, D Sadovnick, A Ebers, G Sadnovich, A Genetics of multiple sclerosis. |
| title | Genetics of multiple sclerosis. |
| title_full | Genetics of multiple sclerosis. |
| title_fullStr | Genetics of multiple sclerosis. |
| title_full_unstemmed | Genetics of multiple sclerosis. |
| title_short | Genetics of multiple sclerosis. |
| title_sort | genetics of multiple sclerosis |
| work_keys_str_mv | AT dymentd geneticsofmultiplesclerosis AT sadovnicka geneticsofmultiplesclerosis AT ebersg geneticsofmultiplesclerosis AT sadnovicha geneticsofmultiplesclerosis |