Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly.
The structural features of the human IgA1 tailpiece required for interaction with J chain in IgA dimer assembly were investigated using a protein engineering approach. Wild-type and mutant forms of IgA1 were expressed in the mouse myeloma cell line, J558L, which endogenously expresses J chain. Wild-...
Main Authors: | Atkin, J, Pleass, R, Owens, R, Woof, J |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
1996
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