Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly.
The structural features of the human IgA1 tailpiece required for interaction with J chain in IgA dimer assembly were investigated using a protein engineering approach. Wild-type and mutant forms of IgA1 were expressed in the mouse myeloma cell line, J558L, which endogenously expresses J chain. Wild-...
Những tác giả chính: | Atkin, J, Pleass, R, Owens, R, Woof, J |
---|---|
Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
1996
|
Những quyển sách tương tự
-
Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells.
Bằng: Morton, H, et al.
Được phát hành: (1993) -
Development of a human IgA antibody specific for the tumor antigen TAG-72
Bằng: Ingram, P, et al.
Được phát hành: (1996) -
Development of a human IgA antibody specific for the tumour antigen TAG-72.
Bằng: Ingram, P, et al.
Được phát hành: (1997) -
Dimeric and polymeric IgA, but not monomeric IgA, enhance the production of IL-6 by human renal mesangial cells
Bằng: T. J. F. Reterink, et al.
Được phát hành: (1996-01-01) -
Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains
Bằng: Hashim, Onn Haji, et al.
Được phát hành: (2001)